2. Anti-infection
  3. Bacterial
  4. TBA-7371

TBA-7371 是口服有效和非共价的、结核分枝杆菌 Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) 的抑制剂 (MIC=0.64 μg/mL)。TBA-7371 可阻断细菌细胞壁阿拉伯糖的合成，导致细胞壁结构缺陷，从而发挥抗结核作用。TBA-7371 可应用于抗结核病药物研究，与 Bedaquiline (HY-14881) 等具有协同杀菌效果。

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TBA-7371 Chemical Structure

TBA-7371 Chemical Structure

CAS No. : 1494675-86-3

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550
In-stock
5 mg ￥500
In-stock
10 mg ￥800
In-stock
25 mg ￥1500
In-stock
50 mg ￥2500
In-stock
100 mg ￥4300
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

TBA-7371 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs[1][2][3].

IC50 & Target

DprE1[1]
体外研究
(In Vitro)

TBA-7371 对结核分枝杆菌 Erdman 株和 H37Rv 株的 MIC 均为 1 μg/mL，在 4% 人血清白蛋白存在下 MIC 仅 2 倍升高，显示与人血清蛋白结合影响较小[2]。
TBA-7371（1、10、100 μg/mL；14 天）对结核分枝杆菌 Erdman 株呈现剂量依赖性杀菌活性，其中 100 μg/mL 组杀菌效果最明显[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TBA-7371 相关抗体:

Cell Viability Assay[1]

Cell Line: Mycobacterium tuberculosis Erdman
Concentration: 1 μg/mL, 10 μg/mL, 100 μg/mL
Incubation Time: 14 days
Result: All concentrations significantly reduced bacterial CFU counts over 14 days compared to the DMSO control, with the 100 μg/ml group showing the highest bactericidal activity, demonstrating dose-dependent killing.
体内研究
(In Vivo)

TBA-7371 (100、200 mg/kg；口服灌胃；每日两次；5/7 天每周，共 4 周) 在 BALB/c 小鼠结核病模型中，与 Bedaquiline (HY-14881) 和 GSK2556286 (HY-147017) 协同发挥杀菌和灭菌活性[3]。
TBA-7371 (50、100、200 mg/kg；口服灌胃；每日两次；5/7 天每周，共 8 周) 在 C3HeB/Fe J小鼠结核病模型中，处理 8 周后肺组织细菌负荷显著降低[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (5-6 weeks old, specific pathogen-free) + subacute tuberculosis infection model induced by aerosol of Mycobacterium tuberculosis H37Rv[3]
Dosage: 100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration: Oral gavage, twice daily (8 h apart), 5 days/week for 4-8 weeks; Combination with Bedaquiline (25 mg/kg) and GSK2556286 (50 mg/kg) (BGA regimen)
Result: At 100 or 200 mg/kg bid significantly increased bactericidal activity after 8 weeks, with lung CFU counts of 1.48 (200 mg/kg) and 1.78 (100 mg/kg), demonstrating superior sterilizing activity compared to two-drug combinations.
Animal Model: Female C3HeB/FeJ mice (8-10 weeks old, specific pathogen-free) + chronic tuberculosis infection model with caseous necrotic pulmonary lesions induced by aerosol of Mycobacterium tuberculosis Erdman[3]
Dosage: 50 mg/kg, 100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration: Oral gavage, twice daily, 5 days/week for 8 weeks
Result: After 8 weeks, all dose groups showed significant reduction in lung bacterial burden compared to untreated controls.
The 100 and 200 mg/kg groups achieved approximately 1.5 log CFU reduction, with dose-dependent efficacy.
At 100 mg/kg bid exhibited consistent bactericidal activity, with higher drug retention in caseous lesions at trough concentrations.
Clinical Trial
分子量

355.39

Formula

C18H21N5O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (70.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8138 mL 14.0691 mL 28.1381 mL
5 mM 0.5628 mL 2.8138 mL 5.6276 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

TBA-7371 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8138 mL 14.0691 mL 28.1381 mL 70.3453 mL
5 mM 0.5628 mL 2.8138 mL 5.6276 mL 14.0691 mL
10 mM 0.2814 mL 1.4069 mL 2.8138 mL 7.0345 mL
15 mM 0.1876 mL 0.9379 mL 1.8759 mL 4.6897 mL
20 mM 0.1407 mL 0.7035 mL 1.4069 mL 3.5173 mL
25 mM 0.1126 mL 0.5628 mL 1.1255 mL 2.8138 mL
30 mM 0.0938 mL 0.4690 mL 0.9379 mL 2.3448 mL
40 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.7586 mL
50 mM 0.0563 mL 0.2814 mL 0.5628 mL 1.4069 mL
60 mM 0.0469 mL 0.2345 mL 0.4690 mL 1.1724 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBA-73711494675-86-3TBA7371TBA 7371BacterialDprE1noncovalentantitubercularantituberculosistuberculosisInhibitorinhibitorinhibit

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