1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC-Me dihydrochloride

(S,R,S)-AHPC-Me dihydrochloride (Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride)

目录号: HY-42424A
产品使用指南

(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) 是一种基于 (S,R,S)-AHPC 的,可募集 von Hippel-Lindau (VHL) 蛋白的 VHL 配体。(S,R,S)-AHPC-Me dihydrochloride 可用于合成 ARV-771。ARV-771 是一种基于 VHL E3 连接酶的 BET PROTAC 降解剂。ARV-771 可有效降解去势抵抗性前列腺癌 (CRPC) 细胞中的 BET 蛋白,DC50 <1 nM。

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(S,R,S)-AHPC-Me dihydrochloride Chemical Structure

(S,R,S)-AHPC-Me dihydrochloride Chemical Structure

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2750 In-stock
100 mg ¥2500 In-stock
500 mg ¥7500 In-stock
1 g ¥12000 In-stock
2 g ¥18000 In-stock
5 g   Get quote  
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Description

(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].

IC50 & Target

VHL

 

Molecular Weight

517.51

Formula

C₂₃H₃₄Cl₂N₄O₃S

SMILES

N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9323 mL 9.6616 mL 19.3233 mL
5 mM 0.3865 mL 1.9323 mL 3.8647 mL
10 mM 0.1932 mL 0.9662 mL 1.9323 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-MeVHL ligand 2E3 ligase Ligand 1VHL ligand2VHL ligand-2Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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产品名称:
(S,R,S)-AHPC-Me dihydrochloride
目录号:
HY-42424A
需求量: