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  2. TNF Receptor Bacterial
  3. Etanercept

Etanercept  (Synonyms: 依那西普)

目录号: HY-108847 纯度: 99.20%
COA

Etanercept 是一种结合肿瘤坏死因子 (TNF) 的二聚体融合蛋白,作为 TNF 抑制剂。Etanercept 竞争性地抑制 TNF-α 和 TNF-β 与细胞表面 TNF 受体的结合,使肿瘤坏死因子在生物学上失去活性。Etanercept 对风湿性关节炎、幼年特发性关节炎和斑块性银屑病有效。

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Etanercept Chemical Structure

Etanercept Chemical Structure

CAS No. : 185243-69-0

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

IC50 & Target[1][2]

Fas

 

体内研究
(In Vivo)

Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
Dosage: 10 mg/kg
Administration: S.c.; every 3 days for 3 weeks
Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
Clinical Trial
分子量

150000 (Average)

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依那西普

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 99.20%

参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Etanercept
目录号:
HY-108847
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