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  3. L-Moses

L-Moses  (Synonyms: L-45)

目录号: HY-101125 纯度: ≥99.0%
COA 产品使用指南

L-Moses (L-45) 是第一个有效的选择性 p300/CBP 相关因子 (PCAF) 溴结构域 (Brd) 抑制剂,Kd 为 126 nM。

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L-Moses Chemical Structure

L-Moses Chemical Structure

CAS No. : 2079885-05-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3740
询价
1 mg ¥1500
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5 mg ¥3400
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10 mg ¥5500
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100 mg   询价  

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Top Publications Citing Use of Products
WB

    L-Moses purchased from MCE. Usage Cited in: EMBO Rep. 2020 Mar 4;21(3):e48328.  [Abstract]

    Inhibiting acetyltransferases CBP/P300 by TPOP146 (134 nM) or PCAF by L-45 (126 nM) for 24 h did not significantly decrease the K49-acetylated b-cat level in Tau-overexpressing N2a cells (n = 3 biological replicates each group)
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM[1].

    IC50 & Target

    Brd

    126 nM (Kd)

    体外研究
    (In Vitro)

    L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A structure using highly homologous (64 % identity) Brd from Plasmodium falciparum, PfGCN5, of which L-Moses is also a potent ligand (isothermal titration calorimetry (ITC) KD 280 nM), is successfully obtained (PDB: 5TPX). L-Moses binds in the acetylated lysines (KAc) -binding pocket of PfGCN (blue ribbon and sticks) and makes H-bonds (dotted lines) through the triazole to N1436 and the first of a network of four water molecules (red spheres)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    360.46

    Formula

    C21H24N6

    CAS 号
    性状

    固体

    颜色

    White to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 33.33 mg/mL (92.47 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.7742 mL 13.8712 mL 27.7423 mL
    5 mM 0.5548 mL 2.7742 mL 5.5485 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.97%

    参考文献

    L-Moses 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7742 mL 13.8712 mL 27.7423 mL 69.3558 mL
    5 mM 0.5548 mL 2.7742 mL 5.5485 mL 13.8712 mL
    10 mM 0.2774 mL 1.3871 mL 2.7742 mL 6.9356 mL
    15 mM 0.1849 mL 0.9247 mL 1.8495 mL 4.6237 mL
    20 mM 0.1387 mL 0.6936 mL 1.3871 mL 3.4678 mL
    25 mM 0.1110 mL 0.5548 mL 1.1097 mL 2.7742 mL
    30 mM 0.0925 mL 0.4624 mL 0.9247 mL 2.3119 mL
    40 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7339 mL
    50 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3871 mL
    60 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1559 mL
    80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8669 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    L-Moses
    目录号:
    HY-101125
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