2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. McN3716

McN3716  (Synonyms: Methyl palmoxirate; NSC359682)

目录号: HY-U00159
COA 产品使用指南

摩尔计算器

McN3716 是一种肉碱棕榈酰转移酶 I (CPT-1) 抑制剂。

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McN3716 Chemical Structure

McN3716 Chemical Structure

CAS No. : 69207-52-9

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McN3716 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.

IC50 & Target

Carnitine palmitoyltransferase I (CPT-1)[1]
体内研究
(In Vivo)

Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

298.46

Formula

C18H34O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

帕莫酸甲酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are used. The rats receive ad libitum access to standard chow and water. At 15 weeks of age, six rats were subjected to either high-energy, head-focused microwave irradiation or CO2 asphyxiation. A separate group of 11 rats were implanted with a tail vein catheter (intravenous catheter 24 gauge/0.75 inch) and received either an intravenous injection of vehicle or 10 mg/kg of McN3716. Fifteen minutes after injection, rats were rapidly euthanized by high-energy, head-focused microwave irradiation (13.5 kW for 1.6 seconds) to avert ischemia for accurate quantification of in vivo basal levels of nonenzymatic auto-oxidative PUFA metabolites and enzymatically derived metabolites. Previously, we reported that this method reduced β-oxidation of fatty acid by 23% to 74%. McN3716 (Methyl palmoxirate, MEP) readily crosses the blood–brain barrier with a plasma half-life of 0.6 minute in the rat. The brain was excised and stored at -80°C for lipidomics profiling.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

McN3716 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

McN371669207-52-9Methyl palmoxirate NSC359682帕莫酸甲酯McN 3716McN-3716NSC359682NSC 359682NSC-359682Mitochondrial MetabolismInhibitorinhibitorinhibit

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