2. Anti-infection Apoptosis Membrane Transporter/Ion Channel Stem Cell/Wnt
  3. Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
  4. Monensin

Monensin  (Synonyms: Monensin A)

目录号: HY-N4302
产品使用指南

摩尔计算器

Monensin (Monensin A) 是一种具有口服活性的抗生素 (antibiotic)，是一种介导 Na+/H+ 交换的离子载体。Monensin 是一种有效的 Wnt 信号传导抑制剂。Monensin 导致多泡体（MVB）显着增大并调节外泌体分泌。Monensin 可用于细菌、真菌和寄生虫感染研究，并显示出抗癌作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Monensin sodium 通常具有更好的水溶性和稳定性。

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Monensin Chemical Structure

Monensin Chemical Structure

CAS No. : 17090-79-8

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Monensin 的其他形式现货产品:

Customer Review

Other Forms of Monensin:

Monensin 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects[1][2][3][4].

体外研究
(In Vitro)

Monensin（1-5 μM；48 小时）会导致活力显着下降，且呈剂量依赖性[1]。
Monensin（1-5 μM；24 小时）显示出统计显着的细胞凋亡诱导作用[1]。
Monensin（0.1-1 μM；24 小时）抑制 pEGFR 及其下游靶点 pAKT 和 pERK[1]。
SCC25 cells[1] 1 μM, or 5 μM 24 hours Induced a potent apoptotic response. SCC9 and SCC25 cells[1] 0.1 μM, or 1 μM 24 hours Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Monensin 相关抗体:

Cell Viability Assay[1]

Cell Line: SCC9, SCC25, and GM-38 cell lines
Concentration: 1-5 μM
Incubation Time: 48 h
Result: Resulted in a marked decrease in viability in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SCC25 cells
Concentration: 1 μM, or 5 μM
Incubation Time: 24 hours
Result: Induced a potent apoptotic response.

Western Blot Analysis[1]

Cell Line: SCC9 and SCC25 cells
Concentration: 0.1 μM, or 1 μM
Incubation Time: 24 hours
Result: Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.
体内研究
(In Vivo)

Monensin（10 mg/kg；口服；每日；持续 6 周）可抑制多发性肠道肿瘤 (Min) 小鼠肠道肿瘤的进展，且对正常粘膜没有任何毒性迹象[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple intestinal neoplasia (Min) mice (four-week-old) [2]
Dosage: 10 mg/kg
Administration: Orally application; daily; for 6 weeks
Result: Suppressed progression of the intestinal tumors without any sign of toxicity on normal mucosa.
分子量

670.87

Formula

C36H62O11
CAS 号
中文名称

莫能菌素
结构分类
初始来源

Streptomyces spp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Monensin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monensin17090-79-8Monensin A莫能菌素BacterialApoptosisAntibioticParasiteNa+/H+ Exchanger (NHE)FungalWntSodium/hydrogen ExchangerSodium-hydrogen ExchangerbioactiveionophoreStreptomycesprotonsmonovalentapoptosiscancerInhibitorinhibitorinhibit

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