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Trehalose 6-behenate  (Synonyms: 海藻糖 6-山嵛酸酯)

目录号: HY-101871
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Trehalose 6-behenate 是一种 Th1/Th17 疫苗佐剂。

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Trehalose 6-behenate Chemical Structure

Trehalose 6-behenate Chemical Structure

CAS No. : 66755-19-9

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生物活性

Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.

IC50 & Target

Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].

分子量

664.86

Formula

C34H64O12

CAS 号
中文名称

海藻糖 6-山嵛酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Trehalose 6-behenate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Trehalose 6-behenate
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