2. Epigenetics Apoptosis
  3. WDR5 Apoptosis
  4. WDR5-IN-4

WDR5-IN-4 (Compound C6) 是一种染色质相关 WD 重复结构域 5 蛋白 (WDR5) 的 WIN 位点抑制剂，Kd 值为 0.1 nM。WDR5-IN-4 能够从染色质中取代 WDR5，并降低相关基因的表达，引起翻译抑制和核仁应激。具有抗癌作用。

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WDR5-IN-4 Chemical Structure

WDR5-IN-4 Chemical Structure

CAS No. : 2407457-36-5

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规格 价格 是否有货 数量
1 mg ￥1590
In-stock
5 mg ￥3500
In-stock
10 mg ￥5500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of WDR5-IN-4:

WDR5-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WDR5-IN-4 (Compound C6) is a WIN site inhibitor of chromatin-associated WD repeat domain 5 protein (WDR5), Kd The value is 0.1 nM. WDR5-IN-4 is able to displace WDR5 from chromatin and reduce the expression of related genes, causing translation inhibition and nucleolar stress. Has anti-cancer effects [1][1].

IC50 & Target

Kd: 0.1 nM (WIN)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHP-134 GI50
2.7 μM
Compound: 1
Antiproliferative activity against human CHP134 cells expressing wild type p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human CHP134 cells expressing wild type p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
Daudi GI50
6.8 μM
Compound: 1
Antiproliferative activity against human Daudi cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human Daudi cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
K562 GI50
17000 nM
Compound: 1
Antiproliferative activity against human K562 cells assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human K562 cells assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
[PMID: 31858797]
MOLM-13 GI50
900 nM
Compound: 1
Antiproliferative activity against human MOLM13 cells expressing wild type p53 assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MOLM13 cells expressing wild type p53 assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
[PMID: 31858797]
MV4-11 GI50
600 nM
Compound: 1
Antiproliferative activity against human MV4-11 cells expressing wild type p53 assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MV4-11 cells expressing wild type p53 assessed as growth inhibition after 5 days by CellTiter-Glo luminescent assay
[PMID: 31858797]
Raji GI50
16 μM
Compound: 1
Antiproliferative activity against human Raji cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human Raji cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
Ramos GI50
7.1 μM
Compound: 1
Antiproliferative activity against human Ramos cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human Ramos cells expressing mutant p53 assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
SW480 GI50
> 29 μM
Compound: 1
Antiproliferative activity against human SW480 cells assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human SW480 cells assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
SW-620 GI50
6.5 μM
Compound: 1
Antiproliferative activity against human SW620 cells assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
Antiproliferative activity against human SW620 cells assessed as growth inhibition after 5 days by Celltiter-Glo luminescent assay
[PMID: 31858797]
体外研究
(In Vitro)

WDR5-IN-4 (0-50 μM, 3 days) 抑制 MLL1 重排癌细胞 MV4:11 和 K562 细胞的增殖，GI50 分别为 3.20 μM 和 25.4 μM[1]。
WDR5-IN-4 (2 μM, 6 days) 可在 sub-G1 期阻滞 MV4:11 细胞周期，并诱导 MV4:11 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WDR5-IN-4 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MV4:11 and K562
Concentration: 0-50 μM
Incubation Time: 6 days
Result: Arrested the cell cycle at sub-G1 phase.
体内研究
(In Vivo)

WDR5-IN-4（100 μg，宫内注射，单剂量）在 Rnf220+/- 小鼠晚期胚胎阶段促进后脑中的 Hox 基因表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rnf220+/- mouse models[2]
Dosage: 100 μg
Administration: intrauterine injection, single dose
Result: Upregulated the expression of Hox genes.
分子量

498.38

Formula

C25H22Cl2FN5O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

WDR5-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WDR5-IN-42407457-36-5WDR5ApoptosisWD repeat protein-5WD40 repeat domain protein 5MV4:11K562Inhibitorinhibitorinhibit

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