1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Abeprazan hydrochloride

Abeprazan hydrochloride (Synonyms: DWP14012 hydrochloride; Fexuprazan hydrochloride)

目录号: HY-109079A
产品使用指南

Abeprazan (DWP14012) hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂,用于研究与酸相关的疾病。

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Abeprazan hydrochloride Chemical Structure

Abeprazan hydrochloride Chemical Structure

CAS No. : 1902954-87-3

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Abeprazan hydrochloride 的其他形式现货产品:

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生物活性

Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].

体外研究
(In Vitro)

The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

446.87

Formula

C19H18ClF3N2O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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HY-109079A
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