2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Ac-Leu-Leu-Norleucinol

Ac-Leu-Leu-Norleucinol 是钙蛋白酶抑制剂，可用于研究对 Acetaminophen (HY-66005) 引起的急性肝损伤，并能够降低诱导引发的谷草转氨酶 (ALT) 和谷丙转氨酶 (AST) 水平。

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Custom Peptide Synthesis

Ac-Leu-Leu-Norleucinol

Ac-Leu-Leu-Norleucinol Chemical Structure

CAS No. : 148333-42-0

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥450
In-stock
5 mg ￥1080
In-stock
10 mg ￥1710
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ac-Leu-Leu-Norleucinol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].

IC50 & Target

Calpain[1]
体内研究
(In Vivo)

Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen.html" class="link-product" target="_blank">Acetaminophen (HY-66005)-induced acute liver injury in mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1]
Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.)
Administration: Intraperitoneal injection; collected tissue samples 24 hr after
Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).
Injection alone did not cause pathological changes in the liver.
分子量

399.52

Formula

C20H37N3O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (250.30 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5030 mL 12.5150 mL 25.0300 mL
5 mM 0.5006 mL 2.5030 mL 5.0060 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ac-Leu-Leu-Norleucinol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5030 mL 12.5150 mL 25.0300 mL 62.5751 mL
5 mM 0.5006 mL 2.5030 mL 5.0060 mL 12.5150 mL
10 mM 0.2503 mL 1.2515 mL 2.5030 mL 6.2575 mL
15 mM 0.1669 mL 0.8343 mL 1.6687 mL 4.1717 mL
20 mM 0.1252 mL 0.6258 mL 1.2515 mL 3.1288 mL
25 mM 0.1001 mL 0.5006 mL 1.0012 mL 2.5030 mL
30 mM 0.0834 mL 0.4172 mL 0.8343 mL 2.0858 mL
40 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5644 mL
50 mM 0.0501 mL 0.2503 mL 0.5006 mL 1.2515 mL
60 mM 0.0417 mL 0.2086 mL 0.4172 mL 1.0429 mL
80 mM 0.0313 mL 0.1564 mL 0.3129 mL 0.7822 mL
100 mM 0.0250 mL 0.1252 mL 0.2503 mL 0.6258 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Leu-Leu-Norleucinol148333-42-0Proteasomeacetaminophenglutamic-oxalacetic transamineaseglutamic-pyruvic transaminaseInhibitorinhibitorinhibit

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