2. Anti-infection Apoptosis MAPK/ERK Pathway Stem Cell/Wnt NF-κB Metabolic Enzyme/Protease
  3. Antibiotic Apoptosis Caspase JNK p38 MAPK TNF Receptor ERK NF-κB Mitochondrial Metabolism
  4. Acetoxycycloheximide

Acetoxycycloheximide 是一种具有抗肿瘤活性的抗生素。Acetoxycycloheximide 是一种蛋白质合成抑制剂。Acetoxycycloheximide 通过激活 JNK 通路，显著诱导由线粒体释放的 Cytochrome c 介导的 procaspase-3 的活化和随后细胞凋亡 (apoptosis)。Acetoxycycloheximide 通过激活 ERK 和 p38 MAPK，触发细胞表面 TNF-R1 的下调，从而阻止 TNF-α 激活 NF-κB 信号通路。Acetoxycycloheximide 对雌性大鼠的毒性远大于雄性大鼠。Acetoxycycloheximide 可用于炎症和免疫疾病以及癌症的研究。

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Acetoxycycloheximide

Acetoxycycloheximide Chemical Structure

CAS No. : 2885-39-4

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Acetoxycycloheximide 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

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  • 参考文献

生物活性

Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research[1][2][3].

IC50 & Target[1]

Procaspase-3

 

NF-κB

 

分子量

339.38

Formula

C17H25NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acetoxycycloheximide 相关分类

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Keywords:

Acetoxycycloheximide2885-39-4AntibioticApoptosisCaspaseJNKp38 MAPKTNF ReceptorERKNF-κBMitochondrial Metabolismc-Jun N-terminal kinaseTumor Necrosis Factor ReceptorTNFRExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBAntitumorJNK pathwayNF-κB signaling pathwayFemale ratsInflammatory and immune diseasesCancersInhibitorinhibitorinhibit

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