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Adenosine N1-oxide 是一种具有口服活性的抗炎剂，可从蜂王浆中分离得到。Adenosine N1-oxide 促进成骨和成脂分化。

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Adenosine N1-oxide Chemical Structure

Adenosine N1-oxide Chemical Structure

CAS No. : 146-92-9

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Adenosine N1-oxide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2].

体外研究
(In Vitro)

Adenosine N1-oxide )(1-40 μM, 24 h) 对 2µg/mL LPS (HY-D1056) 诱导的RAW264.7细胞 TNF-α 和 IL-6 分泌有抑制作用[2]。
Adenosine N1-oxide )(20/100 μM, 30 mins 增加腹腔巨噬细胞和 RAW264.7 细胞内 cAMP 的产生，并呈剂量依赖性[2]。
Adenosine N1-oxide )(5-10 μM, 30 mins) 增加 2µg/mL LPS (HY-D1056) 刺激的 RAW264.7 细胞中 Akt 和 GSK-3β 磷酸化水平[2]。
[2]。
Adenosine N1-oxide )(1-40 μM, 24 h) 促进 MC3T3-E1 细胞成骨和成脂分化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine N1-oxide 相关抗体:

Western Blot Analysis[2]

Cell Line: RAW264.7 cells
Concentration: 2, 5 and 10 μM
Incubation Time: 30 mins
Result: Increased the protein level of phosphorylation of Akt and GSK-3β in 2 µg/mL LPS (HY-D1056)-stimulated RAW264.7 cells.

Cell Differentiation Assay[2]

Cell Line: MC3T3-E1 cells
Concentration: 2, 5 and 10 μM
Incubation Time: 6-7 days
Result: Promoted osteogenic and adipocyte differentiation in MC3T3-E1 cells
体内研究
(In Vivo)

Adenosine N1-oxide (口服，135 mg/kg，三次) 可降低 LPS (HY-D1056) 诱导的 BALB/c 小鼠内毒素休克的致死率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced endotoxin shock in BALB/c mice[1]
Dosage: 135 mg/kg for three times
Administration: Oral administration
Result: Reduced the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice.
分子量

283.24

Formula

C10H13N5O5
CAS 号
结构分类
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine N1-oxide146-92-9Others3T3-L1mesenchymal stem cellmacrophageanti-inflammatorycell differentiationInhibitorinhibitorinhibit

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目录号：
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