2. Cell Cycle/DNA Damage PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Apoptosis Anti-infection
  3. CDK Akt ERK Apoptosis Bacterial
  4. Albanol B

Albanol B 是一种芳基苯并呋喃衍生物，可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖，下调 CDK1 表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2 的磷酸化水平。

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Albanol B Chemical Structure

Albanol B Chemical Structure

CAS No. : 87084-99-9

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规格 价格 是否有货 数量
1 mg ￥3100
In-stock
5 mg ￥9350
In-stock
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50 mg   询价  

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Albanol B 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1].

体外研究
(In Vitro)

Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力[1]。
Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡[1]。
Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Albanol B 相关抗体:

Cell Viability Assay[1]

Cell Line: A549 cells, BZR, NCI-H1975, and NCI-H226 cells
Concentration: 0, 1, 3, 10, and 30 μM
Incubation Time: 48 hours
Result: Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively.

Cell Cycle Analysis[1]

Cell Line: A549 and H1975 cells
Concentration: 1, 3, 10 μM
Incubation Time: 48 hours
Result: Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 1 h, 3 h, 6 h, and 9 h
Incubation Time: 48 hours
Result: Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners.
Did not increase the phosphorylation level of JNK and p38 MAPKs.
体内研究
(In Vivo)

Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: EX-3LL tumor-bearing mice[1]
Dosage: 50 mg/kg, 100 mg/kg
Administration: IP; once daily for 21 days
Result: Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
分子量

558.53

Formula

C34H22O8
CAS 号
性状

固体

颜色

Off-white to gray

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Albanol B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Albanol B87084-99-9CDKAktERKApoptosisBacterialCyclin dependent kinasePKBProtein kinase BExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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