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Alendronate sodium  (Synonyms: Alendronic acid monosodium salt)

目录号: HY-108685 纯度: 98.0%
COA 产品使用指南 技术支持

Alendronate sodium 是一种具有口服活性的含氮双膦酸盐。Alendronate sodium 有效抑制骨吸收。Alendronate sodium 用于绝经后骨质疏松症的研究。

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Alendronate sodium

Alendronate sodium Chemical Structure

CAS No. : 129318-43-0

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规格 价格 是否有货 数量
100 mg ￥500
In-stock
500 mg ￥1600
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Alendronate sodium:

Alendronate sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BMDM IC50
3.7 μM
Compound: Alen
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
[PMID: 31257875]
BMMC IC50
1.71 μM
Compound: Alendronate
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
[PMID: 33485256]
RAW264.7 IC50
0.084 μM
Compound: AS
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
10.1039/C5MD00482A
Clinical Trial
分子量

271.08

Formula

C4H12NNaO7P2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 25 mg/mL (92.22 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6889 mL 18.4447 mL 36.8895 mL
5 mM 0.7378 mL 3.6889 mL 7.3779 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.0%

COA (289 KB) HNMR (260 KB) CNMR (253 KB)

产品使用指南 (1538 KB)
参考文献

Alendronate sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6889 mL 18.4447 mL 36.8895 mL 92.2237 mL
5 mM 0.7378 mL 3.6889 mL 7.3779 mL 18.4447 mL
10 mM 0.3689 mL 1.8445 mL 3.6889 mL 9.2224 mL
15 mM 0.2459 mL 1.2296 mL 2.4593 mL 6.1482 mL
20 mM 0.1844 mL 0.9222 mL 1.8445 mL 4.6112 mL
25 mM 0.1476 mL 0.7378 mL 1.4756 mL 3.6889 mL
30 mM 0.1230 mL 0.6148 mL 1.2296 mL 3.0741 mL
40 mM 0.0922 mL 0.4611 mL 0.9222 mL 2.3056 mL
50 mM 0.0738 mL 0.3689 mL 0.7378 mL 1.8445 mL
60 mM 0.0615 mL 0.3074 mL 0.6148 mL 1.5371 mL
80 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alendronate129318-43-0Alendronic acid monosodiumOthersosteoporosisosteogenesisadipogenesisoralbisphosphonateInhibitorinhibitorinhibit

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