1. Anti-infection Epigenetics
  2. Parasite Histone Methyltransferase
  3. Amodiaquine-d10

Amodiaquine-d10  (Synonyms: 阿莫地喹-d10)

目录号: HY-B1322AS 纯度: ≥97.0%
COA 产品使用指南

Amodiaquine-d10 是 Amodiaquine 的氘代物。Amodiaquine (Amodiaquin) 是一种4-氨基喹啉类抗疟剂,是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂。Amodiaquine 也是一种 Nurr1 激动剂,可特异性结合 Nurr1 的配体结合域,EC50 为 ~20 μM。抗炎作用。

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Amodiaquine-d<sub>10</sub> Chemical Structure

Amodiaquine-d10 Chemical Structure

CAS No. : 1189449-70-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amodiaquine-d10 is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

365.92

Formula

C20H12D10ClN3O

CAS 号
性状

固体

颜色

White to off-white

中文名称

阿莫地喹-d10

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

参考文献
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