2. Immunology/Inflammation Apoptosis JAK/STAT Signaling Stem Cell/Wnt
  3. CD276/B7-H3 Apoptosis STAT
  4. Anti-Mouse CD276/B7-H3 Antibody (MJ18)

Anti-Mouse CD276/B7-H3 Antibody (MJ18) 

目录号: HY-P990279 纯度: 95.00%
COA 技术支持

Anti-Mouse CD276/B7-H3 Antibody (MJ18) 是一种大鼠来源的抗小鼠 CD276/B7-H3 IgG1 单克隆抗体。Anti-Mouse CD276/B7-H3 Antibody (MJ18) 可以抑制 CD276/B7-H3 并诱导肿瘤细胞凋亡 (apoptosis)。Anti-Mouse CD276/B7-H3 Antibody (MJ18) 通过减少免疫抑制细胞和促进 T 细胞活化来增强抗肿瘤免疫反应。Anti-Mouse CD276/B7-H3 Antibody (MJ18) 可用于癌症如乳腺癌和前列腺癌的研究。

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Anti-Mouse CD276/B7-H3 Antibody (MJ18)

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Chemical Structure

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Anti-Mouse CD276/B7-H3 Antibody (MJ18) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD276/B7-H3 Antibody (MJ18) is a rat-derived anti-mouse CD276/B7-H3 IgG1 monoclonal antibody. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can inhibit CD276/B7-H3 and induce tumor cell apoptosis. Anti-Mouse CD276/B7-H3 Antibody (MJ18) enhances anti-tumor immune response by reducing immunosuppressive cells and promoting T cell activation. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can be used for research on cancer such as breast cancer and prostate cancer[1][2][3].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1]

p-STAT3

 

体内研究
(In Vivo)

Anti-Mouse CD276/B7-H3 Antibody (MJ18) (0.3 mg/小鼠，腹腔注射，每隔一天一次，从第 12 天到第 30 天) 显著抑制了 Tamoxifen (HY-13757A) 诱导的 Tgfbr1/Pten 2cKO 小鼠的肿瘤生长并增强了 T 细胞活性[1]。
Anti-Mouse CD276/B7-H3 Antibody (MJ18) (160 μg，腹腔注射，每周两次，持续 2 周) 显著抑制携带 4T1 肿瘤的雌性 BALB/c 小鼠的肿瘤生长并增加 CD8+ T 细胞浸润[2]。
Anti-Mouse CD276/B7-H3 Antibody (MJ18) (10 mg/kg，腹腔注射，每周三次，持续 4 周) 显著抑制了 N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) (HY-W755252) 诱导的 Rosa-CD276 C57BL/6 小鼠的肿瘤生长，协同增加了 CD8+ T 细胞浸润和肿瘤细胞凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The Squamouth Cell Carcinomas of the Head and Neck model consists of Tgfbr1/Pten 2cKO mice induced with Tamoxifen (2 mg/kg, p.o., for 5 days)[1]
Dosage: 0.3 mg/mouse
Administration: Intraperitoneal injection (i.p.), once every other day, from day 14 to 30
Result: Significantly inhibited tumor growth and reduced tumor burden.
Reduced lymph node enlargement and spleen index.
Reduced the expression of p-STAT3, CXCL1, CCL2, and B7-H3.
Reduced myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs) and enhanced T cell activity.
Animal Model: 1×107 4T1 cells injected female BALB/c mice (5-6 weeks)[2]
Dosage: 160 μg, combined with TVB-3166 (30 mg/kg, p.o., once daily) (HY-120394) and PD-L1 mAb (200 μg, i.p., twice weekly)
Administration: Intraperitoneal injection (i.p.), twice weekly for 2 weeks
Result: Inhibited tumor growth and upregulated FASN expression within tumors.
Increased CD8+ T cell infiltration and tumor cell apoptosis.
Animal Model: The bladder cancer consists of BBN induced Rosa-CD276 C57BL/6 mice[3]
Dosage: 10 mg/kg, combined with anti-PD-L1 (200 μg/mouse, on day 1, 3, 5, 7 and 14)
Administration: Intraperitoneal injection (i.p.), three times a week for 4 weeks
Result: Significantly inhibited the volume of tumors.
Increased CD8+ T cell infiltration and tumor cell apoptosis.
基因 ID

102657  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD276/B7-H3 Antibody (MJ18) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD276/B7-H3 Antibody (MJ18)CD276/B7-H3ApoptosisSTATB7 homolog 3 proteinCD276B7-H3breast cancerprostate cancer4T1Inhibitorinhibitorinhibit

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