2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-4 Antibody (11B11)

Anti-Mouse IL-4 Antibody (11B11) 

目录号: HY-P990121 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-4 Antibody (11B11) 是一种抗小鼠 IL-4 IgG1 单克隆抗体。Anti-Mouse IL-4 Antibody (11B11) 可以通过阻断 IL-4 信号通路来抑制 Th2 细胞分化。Anti-Mouse IL-4 Antibody (11B11) 与抗 IL13 单克隆抗体联用可以显著减少纤维化。Anti-Mouse IL-4 Antibody (11B11) 可用于研究癌症和炎症疾病，如结直肠癌和前列腺炎。

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Anti-Mouse IL-4 Antibody (11B11) Chemical Structure

Anti-Mouse IL-4 Antibody (11B11) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1200
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5 mg ￥3600
In-stock
10 mg ￥6200
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100 mg   询价  

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Anti-Mouse IL-4 Antibody (11B11) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combination with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for research on cancer and inflammation conditions such as colorectal cancer and prostatitis[1][2][3].

IC50 & Target[1][2][3]

IL-4

 

体外研究
(In Vitro)

Anti-Mouse IL-4 Antibody (11B11) (10 μg/mL) 在 TGF-β1 和 IL-2 存在的情况下有助于抑制实验性自身免疫性前列腺炎 (EAP) 小鼠脾脏中 CD4+ T 细胞中 Th2 细胞的分化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-4 Antibody (11B11) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-4 Antibody (11B11) (1 mg, 腹腔注射, 每日一次, 持续 10 天) 显著增加了 II 型胶原诱导性关节炎的雌性 DBA/1J 小鼠的关节炎发病率[1]。
Anti-Mouse IL-4 Antibody (11B11) (500 μg/小鼠, 腹腔注射, 单次剂量, APTKA mCherry 类器官注射前 1 小时) 联合抗 IL-13 单克隆抗体通过阻断 IL-4/IL-13 信号通路，显著降低了携带 APTKA mCher 类器官的 C57BL/6 小鼠的胶原沉积和 Col1a1 表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Type II collagen (50 μg) induced arthritis in female DBA/1J mice[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 10 days
Result: Significantly increased incidence of arthritis (33% on day 18, 100% on day 26).
Significantly increased the severity of arthritis compared to the control group.
Significantly increased IgG2a antibody levels and decreased IgG1 antibody levels.
Enhanced delayed type hypersensitivity (DTH) of foot pads.
Significantly inhibited the secretion of IL-4 and increased the secretion of IFN-γ in lymph node cells from inguinal region of mice.
Significantly enhanced the proliferation response of lymph node cells to collagen II.
Animal Model: C57BL/6 mice bearing APTKA mCherry organoid (8-12 weeks)[3]
Dosage: 500 μg/mouse, with anti-IL-13 mAb (200 μg)
Administration: Intraperitoneal injection (i.p.), single dose, 1 hour before APTKA mCherry organoid injection
Result: Reduced fibrosis and metastasis by blocking the IL-4/IL-13 signaling pathway.
基因 ID

16189  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-4 Antibody (11B11) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-4 Antibody (11B11)Interleukin RelatedILIL-4IL13colorectalprostatitisInhibitorinhibitorinhibit

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