Il4 - interleukin 4 Gene

中文名称：白细胞介素 4

种属: Mus musculus

同用名: Il-4; BSF-1

关于 Il4

功能概要

该基因编码的蛋白可启动细胞因子活性。参与多个过程，包括粘膜中的先天免疫反应；白色脂肪细胞增殖的负调节；和基因表达的调控。作用于多个过程的上游或内部，包括 T 辅助细胞分化；大分子代谢过程的正向调控；和白细胞活化的调节。位于质膜和细胞外间隙的外侧。以多种结构表达，包括大脑；冒号;淋巴系统；肝;和胎盘。用于研究干燥综合征；特应性皮炎;和 1 型糖尿病。该基因的人类直系同源物与多种疾病有关，包括哮喘（多种）；自身免疫性疾病（多种）；乙型肝炎；丙型肝炎;和胰腺癌（多发）。与人 IL4（白细胞介素 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]