Anti-Mouse PD-1 Antibody (29F.1A12) 

Anti-Mouse PD-1 Antibody (29F.1A12) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-1. Anti-Mouse PD-1 Antibody (29F.1A12) blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2. Anti-Mouse PD-1 Antibody (29F.1A12) can be used for the researches of cancer and immunology, such as CT26 tumor and pancreatic cancer^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

PD-1

Anti-Mouse PD-1 Antibody (29F.1A12) (10 μg/mL, 7 days) 与抗 CTLA-4 联合使用时，可增加来自 CT26 肿瘤的 CD8⁺CTLA-4⁺PD-1⁺ 肿瘤浸润淋巴细胞中 IFN-γ 细胞因子的产生和 Ki-67 的表达^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse PD-1 Antibody (29F.1A12) (200 μg，腹腔注射，在第 10、13 和 16 天给药) 与抗 CTLA-4 联合使用可使 CT26/ID8-VEGF 肿瘤小鼠的肿瘤消退^[1]。
Anti-Mouse PD-1 Antibody (29F.1A12) (100 μg，腹腔注射，在 BRAF 抑制剂给药后的第 1、3 和 5 天给药) 与 BRAF 抑制剂联合使用可延缓 BP 肿瘤小鼠的肿瘤生长并提高生存率^[2]。
Anti-Mouse PD-1 Antibody (29F.1A12) (200 μg，腹腔注射，在第 4、7 和 10 天给药) 与 PRIP1 抑制剂联合使用可保护胰腺癌小鼠免受原发性胰腺癌和肝转移的侵害^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

18566  [NCBI]

Q02242

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Duraiswamy J, et al. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013 Jun 15;73(12):3591-603.  [Content Brief]

  [2]. Cooper ZA, et al. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul;2(7):643-54.  [Content Brief]

  [3]. Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34(5):757-774.e7.  [Content Brief]