2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11)

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 

目录号: HY-P990823
技术支持

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 是一种大鼠源性 IgG2b κ 型抗体抑制剂，靶向 PD-L1/B7-H1。Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 可阻断 PD-L1/B7-1 相互作用，但不阻断 PD-L1/PD-1 相互作用。Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 可用于癌症、感染、免疫学和代谢性疾病的研究，如 MB49 肿瘤、心脏移植和糖尿病。

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Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11)

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) Chemical Structure

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Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) is rat-derived IgG2b κ type antibody inhibitor, targeting to PD-L1/B7-H1. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can block PD-L1/ B7-1 interactions and does not block PD-L1/PD-1 interactions. Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) can be used for the researches of cancer, infection, immunology and metabolic disease, such as MB49 tumor, heart graft and diabetes[1][2][3][4].

同型

Rat IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

PD-L1/B7-H1
体外研究
(In Vitro)

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) (3 h) 不影响来自 PD-1A 转基因小鼠的 CD4+ 和 CD8+ T 细胞中的 T 细胞增殖[2]。
Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) (50 μg/mL, 1 h) 可减少树突状细胞中单纯疱疹病毒 (HSV)-CD80 的复制[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) (5 mg/kg，每 3 天一次，共 4 次) 对 MB49 荷瘤小鼠的肿瘤生长无抑制作用[1]。
Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) (第 0 天 0.5 mg，第 2、4、6、8 和 10 天 0.25 mg，腹腔注射) 可诱导非肥胖性糖尿病的自身免疫性糖尿病小鼠发生糖尿病[2]。
Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) (第 0 天 0.5 mg，第 2、4、6 和 8 天 0.25 mg，腹腔注射) 会加重移植到 PD1 缺陷小鼠体内的 bm12 心脏的血管病变，并加速移植物排斥反应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Not obese diabetes of autoimmune diabetes mice(6-7 weeks or 13 weeks)[1]
Dosage: 0.5 mg at day 0 and 0.25 mg at days 2, 4, 6, 8 and 10
Administration: Intraperitoneally injection
Result: Led to diabetes in 40% of 6-7-week mice over a 14 day period.
Led to diabetes in 80% of 13-week mice over a two-week period.
Showed marked infiltrates in pancreata.
Animal Model: Bm12 hearts transferred PD1-deficient mice[3]
Dosage: 0.5 mg at day 0 and 0.25 mg at days 2, 4, 6 and 8
Administration: Intraperitoneally injection
Result: Showed median survival time of 10 days.
Increased the frequency of alloreactive T cells producing IFN-γ.
Enhanced Th1 and Th2 alloimmune responses.
Decreased regulatory T cell.
基因 ID

60533  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse PD-L1/B7-H1 Antibody (10F.2H11)PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1PD-1B7-H1,B7-1T cellMB49GraftDiabetesHSVInhibitorinhibitorinhibit

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