2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse RGMb Antibody (307.9D1)

Anti-Mouse RGMb Antibody (307.9D1) 

目录号: HY-P990164
技术支持

Anti-Mouse RGMb Antibody (307.9D1) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 RGMb。Anti-Mouse RGMb Antibody (307.9D1) 可阻断 RGMb 与 PD-L2 的结合。Anti-Mouse RGMb Antibody (307.9D1) 可用于癌症炎症和免疫学研究，如急性髓系白血病 (AML) 和移植物抗宿主病 (GVHD)。

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Anti-Mouse RGMb Antibody (307.9D1)

Anti-Mouse RGMb Antibody (307.9D1) Chemical Structure

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Anti-Mouse RGMb Antibody (307.9D1) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse RGMb Antibody (307.9D1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse RGMb. Anti-Mouse RGMb Antibody (307.9D1) blocks RGMb binding to PD-L2. Anti-Mouse RGMb Antibody (307.9D1) can be used for the researches of cancer inflammation and immunology, such as acute myeloid leukemia (AML) and graft versus-host disease (GVHD)[1][2][3][4].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

RGMb
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse RGMb Antibody (307.9D1) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse RGMb Antibody (307.9D1) (100 μg，腹腔注射，在肿瘤植入后第 7、10、13、16 天给药) 可抑制 MC38 肿瘤小鼠模型中的肿瘤生长[1]。
Anti-Mouse RGMb Antibody (307.9D1) (诱导前给 450 μg，诱导 2 天后给 200 μg，腹腔注射) 可抑制卵清蛋白诱导的呼吸道耐受小鼠模型中呼吸道耐受的形成，并增加 T 细胞增殖和 IL-4 的产生[2]。
Anti-Mouse RGMb Antibody (307.9D1) (200 μg，腹腔注射，每 3 天一次，共 6 次) 在急性髓系白血病小鼠模型中与抗 PD1 和抗 TIM3 联合使用时，可适度延迟明显白血病的发作，并略微提高生存率[3]。
Anti-Mouse RGMb Antibody (307.9D1) (20 mg/kg，腹腔注射，在第 -1、3 和 7 天给药) 可抑制移植物抗宿主病，并提高 NSG 小鼠的生存率[4]。
Anti-Mouse RGMb Antibody (307.9D1) (200 μg/mouse，腹腔注射，在第 -1、3 和 7 天给药) 可保护小鼠在硫酸葡聚糖钠盐 (DSS) (HY-116282C) 诱导的结肠炎小鼠模型中免于体重减轻和死亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 tumor mice models[1]
Dosage: 100 μg
Administration: Intraperitoneally injection, at days 7, 10, 13, 16 post tumor implantation companied with anti-PD-1 or anti-PD-L1
Result: Attenuated tumor growth.
Increased CD8+ and CD4+ T cells and the CD8+ to Treg cell ratio.
Significantly increased TNF-α production by CD4+ T cells.
Animal Model: Ovalbumin-induced respiratory tolerance mice models[2]
Dosage: 450 μg before induction and 200 μg at 2 days after induction
Administration: Intraperitoneally injection
Result: Developed severe AHR upon rechallenge with OVA.
Had fewer OVA-responsive T cells.
Impaired T cell expansion to antigen.
Reduced the initial expansion of antigen-specific T cells.
Animal Model: Mice were injected with murine syngeneic DC/AML fusion cells[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days for 6 times companied with anti-PD1 and anti-TIM3
Result: Modestly delayed the onset of demonstrable leukemia with mildly improved survival.
Animal Model: Mice were injected with human PMBC to create graft versus-host disease (GVHD)[4]
Dosage: 20 mg/kg
Administration: Intraperitoneally injection, at days -1, 3 and 7
Result: Markedly decreased immune destruction of small and large intestinal villi and ameliorated the GVHD histology score.
Decreased frequency of CD3+ T cells and IL-5, 17, 13, GM-CSF and IFN-γ.
基因 ID

68799  [NCBI]

Accession

Q7TQ33 / NP_848730.2
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse RGMb Antibody (307.9D1) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse RGMb Antibody (307.9D1)Transmembrane GlycoproteinRGMbPD-L2AMLGVHDMC38DSSCancerT cellsInhibitorinhibitorinhibit

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