2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse TIM-1/CD365 Antibody (3D10)

Anti-Mouse TIM-1/CD365 Antibody (3D10) 

目录号: HY-P990822
技术支持

Anti-Mouse TIM-1/CD365 Antibody (3D10) 是一种源自大鼠的 IgG1 κ 型抗体抑制剂，靶向小鼠 TIM-1/CD365。Anti-Mouse TIM-1/CD365 Antibody (3D10) 能够阻断小鼠 T 细胞免疫球蛋白及黏蛋白结构域 1 (TIM-1，也称为 CD365)。Anti-Mouse TIM-1/CD365 Antibody (3D10) 可用于炎症、免疫学和心血管疾病的研究，如移植物抗宿主病 (GVHD)、气道炎症和动脉粥样硬化。

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Anti-Mouse TIM-1/CD365 Antibody (3D10)

Anti-Mouse TIM-1/CD365 Antibody (3D10) Chemical Structure

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Anti-Mouse TIM-1/CD365 Antibody (3D10) 相关抗体

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  • 生物活性

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生物活性

Anti-Mouse TIM-1/CD365 Antibody (3D10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can block mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can be used for the researches of inflammation, immunology and cardiovascular disease, such as graft-versus-host disease (GVHD), airway inflammation and atherosclerosis[1][2][3].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

TIM-1/CD365
体内研究
(In Vivo)

Anti-Mouse TIM-1/CD365 Antibody (3D10) (200 μg，腹腔注射，每周两次，持续 4 周) 在高脂饮食的 ldlr−/− 小鼠中与抗 Tim-4 抗体联合使用会加剧动脉粥样硬化的发展[1]。
Anti-Mouse TIM-1/CD365 Antibody (3D10) (臭氧暴露前 24 小时给药) 可预防野生型小鼠中臭氧诱导的气道高反应性和气道炎症[2]。
Anti-Mouse TIM-1/CD365 Antibody (3D10) (400 μg，腹腔注射，在第 -1、3、7、11 和 17 天给药) 可预防接受同种异体 B6 骨髓和 Tcon 细胞 (H-2b) 的致死性照射 BALB/c (H-2d) 小鼠发生移植物抗宿主病 (GVHD)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High fat diet ldlr−/− mice[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, twice a week for 4 weeks, companied anti-Tim-4 antibody
Result: Increased TUNEL+ cells in lesions.
Impaired efferocytosis.
Enhanced CD4+ T cell numbers within the lesions.
Increased Th2 cytokines in the supernatants of anti-CD3/CD28-stimulated splenocytes.
Induced IgG1 antibodies against oxLDL and MDA-LDL.
Animal Model: Lethally irradiated BALB/c (H-2d) mice received allogeneic B6 BM and Tcon cells (H-2b)[3]
Dosage: 400 μg
Administration: Intraperitoneally injection, at days -1, 3, 7, 11, and 17
Result: Had less GVHD.
Reduced GVHD score and severity.
Reduced inflammatory factors and infiltrating cells.
基因 ID

171283  [NCBI]

Accession

Q5QNS5-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse TIM-1/CD365 Antibody (3D10) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TIM-1/CD365 Antibody (3D10)Transmembrane GlycoproteinTIM-1CD365GVHDAirway inflammationAtherosclerosisOzoneInhibitorinhibitorinhibit

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