1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. VEGFR
    c-Kit
    Src
    RET
    Autophagy
  3. Apatinib free base

Apatinib free base (Synonyms: YN968D1 free base)

目录号: HY-13342A
产品使用指南

Apatinib free base (YN968D1 free base) 是一种口服生物可利用的酪氨酸激酶抑制剂,选择性靶向VEGFR-2 (IC50=1 nM)。Apatinib free base (YN968D1 free base) 是治疗晚期或转移性胃癌的抗血管生成药物。Apatinib free base (YN968D1 free base) 能有效抑制 Retc-Kitc-Src 活性,IC50 值分别为 13,429,530 nM。Apatinib free base (YN968D1 free base) 也抑制 VEGFR-2、c-kit 和 PDGFRβ 的细胞磷酸化。

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Apatinib free base Chemical Structure

Apatinib free base Chemical Structure

CAS No. : 811803-05-1

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Apatinib free base 的其他形式现货产品:

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Other Forms of Apatinib free base:

Top Publications Citing Use of Products

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    The cells are treated with Apatinib (100 nM) for 24 h. The invasion cells were stained.

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    The cells are treated with Apatinib (100 nM) for 24 h. The protein expression of Slug, snail and MMP9 in QBC939 cells and TFK-1 cells are measured by western blot.

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    Protein expression of Slug, snail and MMP9 in si-Control and si-KDR cells when treated with 100 ng/ml rhVEGF or 100 ng/ml rhVEGF + 100 nM apatinib for 24 h.

    Apatinib free base purchased from MCE. Usage Cited in: Oncol Lett. 2019 Feb;17(2):1609-1616.

    The protein levels of CHK2 and pCHK2 are determined by western blotting. Lane 1, control group; lane 2, Apatinib group; lane 3, x‑ray group; and lane 4, combination group.
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    Description

    Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the treatment of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[1][2][3].

    IC50 & Target

    IC50: 1 nM (VEGFR-2), 13 nM (Ret), 429 nM (c-Kit), 530 nM (c-Src)[3]

    Clinical Trial
    Molecular Weight

    397.47

    Formula

    C₂₄H₂₃N₅O

    CAS No.

    811803-05-1

    SMILES

    O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)CCCC4)C=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    ApatinibYN968D1VEGFRc-KitSrcRETAutophagyVascular endothelial growth factor receptorSCFRCD117Inhibitorinhibitorinhibit

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