2. Others Membrane Transporter/Ion Channel Neuronal Signaling
  3. Isotope-Labeled Compounds Sodium Channel Potassium Channel Calcium Channel Calmodulin
  4. Aprindine hydrochloride-d10

Aprindine hydrochloride-d10 是 Aprindine hydrochloride (HY-A0236A) 的氘代物。Aprindine hydrochloride 是一种 Ib 类抗心律失常剂。Aprindine hydrochloride 主要通过阻断钠通道 (INa) 发挥作用，从而降低心肌细胞的兴奋性和传导速度。Aprindine hydrochloride 显著抑制延迟了钾电流，这有助于延长心房有效不应期 (AERP) 并抑制心房颤动的发生。Aprindine hydrochloride 还能通过抑制 Na+/Ca2+ 交换电流 (INCX) 来调节细胞内钙离子浓度，从而进一步稳定心脏电活动。Aprindine hydrochloride 可用于研究心房颤动 (AF) 和室性心律失常。

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Aprindine hydrochloride-d<sub>10</sub>

Aprindine hydrochloride-d10 Chemical Structure

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Aprindine hydrochloride-d10 相关抗体

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  • 生物活性

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生物活性

Aprindine hydrochloride-d10 is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aprindine hydrochloride-d10 相关抗体:
分子量

369.01

Formula

C22H21D10ClN2
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Aprindine hydrochloride-d10 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aprindine hydrochloride-d10Isotope-Labeled CompoundsSodium ChannelPotassium ChannelCalcium ChannelCalmodulinNa channelsNa+ channelsKcsACa2+ channelsCa channelsCaMCalcium-Modulated ProteinInhibitorinhibitorinhibit

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目录号：
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