Aprindine hydrochloride  (Synonyms: 盐酸阿普林定)

Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

Aprindine (3?μM) inhibits the delayed rectifier K⁺?current (I_K) with little influence on the inward rectifier K⁺?current (I_K1) or the Ca²⁺?current^[2].
The muscarinic acetylcholine receptor-operated K⁺?current (I_K.ACh) was activated by the extracellular application of carbachol (1?μM) or by the intracellular loading of GTPγS. Aprindine inhibits the carbachol- and GTPγS-induced I_K.ACh with the IC₅₀?values of 0.4?μM and 2.5?μM, respectively^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

358.95

C₂₂H₃₁ClN₂

33237-74-0

盐酸阿普林定

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M L De Bruin, et al . Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur Heart J. 2005 Mar;26(6):590-7.  [Content Brief]

  [2]. Y Ohmoto-Sekine, et al. Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. Br J Pharmacol. 1999 Feb;126(3):751-61.  [Content Brief]