2. Epigenetics TGF-beta/Smad Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton
  3. PKC ROCK
  4. (rac)-AR-13503

(rac)-AR-13503  (Synonyms: (rac)-AR-13324 M1 metabolite)

目录号: HY-125639
产品使用指南

摩尔计算器

(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) 是 AR-13503 (HY-12798C) 的异构体。AR-13503 是 ROCK/PKC 抑制剂，抑制血管生成，增强视网膜色素上皮 (RPE) 的通透性。AR-13503 还能抑制氧致视网膜病变 (OIR) 小鼠模型中异常新生血管 (NV) 的形成。

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(rac)-AR-13503 Chemical Structure

(rac)-AR-13503 Chemical Structure

CAS No. : 1254032-16-0

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(rac)-AR-13503 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

查看 ROCK 亚型特异性产品:

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ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].

体外研究
(In Vitro)

AR-13503 (16 小时) 抑制人脐静脉内皮细胞 (HUVEC) 管的形成，IC50 为 21 nM[1]。
AR-13503 (400 nM; 5 天) 以剂量依赖的方式减少脉络膜的发芽面积[1]。
AR-13503 (400 nM; 2 周) 以剂量依赖的方式增强猪主要 RPE 屏障功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(rac)-AR-13503 相关抗体:
体内研究
(In Vivo)

AR-13503 (1.25 mg/kg；腹腔注射；每天 1 次，共 5 天) 与 Aflibercept (HY-108801) 有协同作用，显著降低了异常新生血管 (NV) 形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Oxygen-induced retinopathy (OIR) mice model (C57BL/6; 7-days-old)[1]
Dosage: 1.25 mg/kg
Administration: Intraperitoneal injection; once daily for 5 days
Result: The combination group had a greater (~75%) reduction in NV than Aflibercept alone (~55%).
Clinical Trial
分子量

321.37

Formula

C19H19N3O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(rac)-AR-13503 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rac)-AR-135031254032-16-0(rac)-AR-13324 M1 metabolitePKCROCKProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKInhibitorinhibitorinhibit

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