2. Anti-infection
  3. Antibiotic
  4. Artemitin

Artemitin  (Synonyms: 艾黄素)

目录号: HY-N3017 纯度: 99.97%
COA 产品使用指南 技术支持

Artemitin 是一种具有中等细胞毒性的黄酮类神经麻醉试剂。 Artemitin 对 Meth-A 肉瘤细胞具有选择性抑制活性，ED50 为 5-10 μg/mL，对 LLC 肺癌细胞无显著作用。Artemitin 通过影响细胞增殖信号通路发挥抗癌活性，同时具有潜在的抗炎和神经保护作用。Artemitin 在小鼠热板实验中表现出剂量依赖性的抗伤害感受作用，ED50 为 1.6 μg/kg，具有镇痛活性。

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Artemitin Chemical Structure

Artemitin Chemical Structure

CAS No. : 479-90-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥854
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1 mg ￥434
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5 mg ￥1000
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10 mg ￥1500
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25 mg ￥2700
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50 mg ￥4050
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100 mg ￥5670
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200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Artemitin:

Artemitin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 GI50
2200 ng/mL
Compound: 10
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HepG2 IC50
229 μM
Compound: Artemetin
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 31784199]
HL-60 IC50
6.44 μM
Compound: VIII, 5-demethylhexaMF
Antiproliferative activity against HL60 after 24 hrs
Antiproliferative activity against HL60 after 24 hrs
[PMID: 17391969]
Neutrophil IC50
> 10 μg/mL
Compound: 9
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide-anion generation incubated for 5 mins prior to FMLP/CB-challenge measured after 10 mins by spectrophotometry
[PMID: 22429052]
Neutrophil IC50
> 10 μg/mL
Compound: 9
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using Meo-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins prior to FMLP/CB-challenge by spectrophotometry
[PMID: 22429052]
PC-12 GI50
2270 ng/mL
Compound: 10
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
SH-SY5Y IC50
229 μM
Compound: Artemetin
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
[PMID: 31784199]
体外研究
(In Vitro)

Artemitin (10 μg/mL；48 h) 对 Meth-A 肉瘤细胞具有中等细胞毒性 ED50 为 5-10 μg/mL，但对 LLC 肺癌细胞无显著毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Artemitin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Meth-A sarcoma cells, LLC lung carcinoma cells
Concentration: 5-10 μg/mL
Incubation Time: 48 h
Result: Dose-dependent growth inhibition against Meth-A cells, with ED50 values ranging from 5 to 10 μg/ml, while no significant cytotoxic effects were observed in LLC cells under the same conditions.
体内研究
(In Vivo)

Artemitin (10 mg/kg；尾静脉注射；单次；给药后 0.08-6 h 监测) 在雄性 SD 大鼠血浆中的浓度达峰时间，是给药后 0.08 h (Cmax=487.6 μg/L)[2]。
Artemitin (1.6 μg/kg；腹腔注射；单次；给药后 60 min 观察) 在雄性小鼠热板模型中显著延长痛觉反应潜伏期，表现出剂量依赖性抗伤害感受作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pharmacokinetic study in Male SD rats (150-200 g)[2]
Dosage: 10 mg/kg
Administration: Tail vein injection, single dose, blood samples collected at 0.08, 0.17, 0.33, 0.5, 0.75, 1, 2, 3, 4, and 6 h post-administration
Result: After a single intravenous dose of 10 mg/kg, Artemitin rapidly distributed in rats with Cmax achieved at 0.08 h (487.6 μg/L).
The pharmacokinetic parameters were calculated using a two-compartment model, including AUC(0-t)=862.403 μg/L·h, AUC(0-∞)=929.84 μg/L·h), and T1/2=1.556 h, indicating rapid elimination with measurable plasma concentrations up to 6 h.
分子量

388.37

同用名

艾黄素

Formula

C20H20O8
CAS 号
性状

固体

颜色

White to yellow

中文名称

艾黄素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (128.74 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5749 mL 12.8743 mL 25.7486 mL
5 mM 0.5150 mL 2.5749 mL 5.1497 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.97%

COA (288 KB) HNMR (299 KB) RP-HPLC (253 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Artemitin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5749 mL 12.8743 mL 25.7486 mL 64.3716 mL
5 mM 0.5150 mL 2.5749 mL 5.1497 mL 12.8743 mL
10 mM 0.2575 mL 1.2874 mL 2.5749 mL 6.4372 mL
15 mM 0.1717 mL 0.8583 mL 1.7166 mL 4.2914 mL
20 mM 0.1287 mL 0.6437 mL 1.2874 mL 3.2186 mL
25 mM 0.1030 mL 0.5150 mL 1.0299 mL 2.5749 mL
30 mM 0.0858 mL 0.4291 mL 0.8583 mL 2.1457 mL
40 mM 0.0644 mL 0.3219 mL 0.6437 mL 1.6093 mL
50 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2874 mL
60 mM 0.0429 mL 0.2146 mL 0.4291 mL 1.0729 mL
80 mM 0.0322 mL 0.1609 mL 0.3219 mL 0.8046 mL
100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.6437 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Artemitin479-90-3艾黄素AntibioticInhibitorinhibitorinhibit

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