AUTEN-67  (Synonyms: Autophagy enhancer-67)

AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease^[1].

AUTEN-67 (2-100 µM，3 小时) 可抑制 MTMR14 近 3%-70%，诱导自噬流，并促进 HeLa 细胞的存活^[1]。
AUTEN-67 (10-100 µM，2 小时) 通过抑制 EDTP 诱导果蝇自噬^[1]。
AUTEN-67 (1-50 µM) 降低小鼠原代神经元中 LC3B-II 的水平，并保护神经元免受氧化应激 (增加细胞活力)^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AUTEN-67 增强斑马鱼 (10, 50 µM) 和小鼠 (腹腔注射 50 µmol/g 体重) 的自噬^[1]。
AUTEN-67 (19 mg/kg，口服，每周 3 次，持续 3 个月) 可恢复阿尔茨海默病小鼠模型的筑巢行为并降低 APP 水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

474.45

C₂₃H₁₄N₄O₆S

1783800-77-0

固体

Orange to red

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Papp D, et al. AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 2016;12(2):273-86.  [Content Brief]