2. Immunology/Inflammation
  3. Interleukin Related
  4. BAA473

BAA473 是胆汁酸类似物，是一种强效的吡喃类炎症小体激活剂，可通过激活髓样和肠上皮细胞中的炎症小体来诱导 IL-18 的分泌。

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BAA473 Chemical Structure

BAA473 Chemical Structure

CAS No. : 27240-87-5

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BAA473 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1].

IC50 & Target

IL-1

 

体外研究
(In Vitro)

BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BAA473 相关抗体:

Cell Viability Assay[1]

Cell Line: THP-1-Cas9 cells
Concentration: 0 µM, 0.1 µM, 0.4 µM, 1.2 µM, 3.7 µM, 11 µM, 33 µM
Incubation Time: 24 hours
Result: Induced cell death.
分子量

420.58

Formula

C25H40O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BAA473 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAA47327240-87-5BAA 473BAA-473Interleukin RelatedILInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-123879
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