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  2. Pyroptosis Compound Library

细胞焦亡化合物库 - Pyroptosis Compound Library

Cat. No.: HY-L059
Library Contents: XLSX PDF SDF

细胞焦亡(pyroptosis)是细胞程序性死亡的一种方式。与凋亡不同的是,细胞焦亡伴随着炎症反应,在形态学上同时具有坏死和凋亡的特征。焦亡最常发生在病原体感染的细胞中,可以通过刺激免疫反应快速清除细菌、真菌、病毒等的感染。细胞焦亡分为经典途径和非经典途径。炎症性caspases是细胞焦亡中起关键作用的蛋白酶,经典途径由caspase-1介导,而非经典途径中由 Caspase-4/5/11 介导。Caspases 可以诱导 gasdermin-D(GSDMD)的活化和炎症因子白介素 1β(interleukin-1β,IL-1β) 和 IL-18 的分泌,引起细胞肿胀、溶解和炎症反应。细胞焦亡在炎症及感染疾病中得到广泛研究,最近越来越多的研究表明,细胞焦亡在癌症,心血管疾病及代谢紊乱等疾病的发生发展中也发挥重要作用。

MCE 收录了 698 种细胞焦亡相关产品,主要靶向焦亡信号通路中主要靶点,可以用于细胞焦亡信号通路及相关疾病的研究。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 细胞焦亡化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,686 个产品以 10 mM 浓度提供,12 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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sales@MedChemExpress.cn

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Description
& Advantages

•   A unique collection of 698 small molecules used for pyroptosis research.

•   Targets such as Caspase-1, Caspase-4, Caspase-5, gasdermin D, NLRP3 , etc.

•   Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA.

•   A useful tool to study pyroptosis-involved regulation and diseases such as cancer, cardiovascular diseases and Metabolic disorder, etc.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 698 pyroptosis compounds supplied as pre-dissolved Solutions or Solid
Solution: 686 compounds supplied in 10 mM solution, 12 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Documentation

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    产品名称:
    Pyroptosis Compound Library
    目录号:
    HY-L059
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack