2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Batabulin sodium

Batabulin sodium  (Synonyms: T138067 sodium)

目录号: HY-13563A 纯度: 99.76%
COA 产品使用指南

摩尔计算器

Batabulin sodium (T138067 sodium) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管 (microtubule) 聚合。Batabulin sodium 影响细胞形态并导致细胞周期停滞，最终诱导凋亡性细胞死亡。

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Batabulin sodium Chemical Structure

Batabulin sodium Chemical Structure

CAS No. : 195533-98-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650
In-stock
5 mg ￥1500
In-stock
10 mg ￥2200
In-stock
25 mg ￥3800
In-stock
50 mg ￥5600
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Batabulin sodium:

Batabulin sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death[1].

IC50 & Target

β-tubulin[1]
体外研究
(In Vitro)

Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary[1].
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis[1].
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Batabulin sodium 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours
Result: Showed an arrest at the G2/M cell-cycle boundary.

Apoptosis Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours or 48 hours
Result: 25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
体内研究
(In Vivo)

Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; once per week; on days 5, 12, and 19
Result: Impaired the growth of the drug-sensitive CCRF-CEM tumors.
Clinical Trial
分子量

393.24

Formula

C13H6F6NNaO3S
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

巴他布林酸钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (317.87 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5430 mL 12.7149 mL 25.4298 mL
5 mM 0.5086 mL 2.5430 mL 5.0860 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Batabulin sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5430 mL 12.7149 mL 25.4298 mL 63.5744 mL
5 mM 0.5086 mL 2.5430 mL 5.0860 mL 12.7149 mL
10 mM 0.2543 mL 1.2715 mL 2.5430 mL 6.3574 mL
15 mM 0.1695 mL 0.8477 mL 1.6953 mL 4.2383 mL
20 mM 0.1271 mL 0.6357 mL 1.2715 mL 3.1787 mL
25 mM 0.1017 mL 0.5086 mL 1.0172 mL 2.5430 mL
30 mM 0.0848 mL 0.4238 mL 0.8477 mL 2.1191 mL
40 mM 0.0636 mL 0.3179 mL 0.6357 mL 1.5894 mL
50 mM 0.0509 mL 0.2543 mL 0.5086 mL 1.2715 mL
60 mM 0.0424 mL 0.2119 mL 0.4238 mL 1.0596 mL
80 mM 0.0318 mL 0.1589 mL 0.3179 mL 0.7947 mL
100 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batabulin195533-98-3T138067巴他布林酸钠T 138067T-138067Microtubule/TubulinApoptosisAntimitoticβ-tubulinantitumormultidrug-resistantpolymerizationCys-239covalentcytoskeletoncell-cyclearrestInhibitorinhibitorinhibit

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产品名称：
Batabulin sodium
目录号：
HY-13563A
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