1. Immunology/Inflammation Apoptosis
  2. Interleukin Related Apoptosis
  3. Bizaxofusp

Bizaxofusp  (Synonyms: MDNA55; NBI-3001; PRX-321)

目录号: HY-P990708
技术支持

Bizaxofusp (MDNA55) 是一种由 IL-4 与截短假单胞菌外毒素连接而成的融合蛋白。Bizaxofusp 能与肿瘤细胞表面 IL-4 受体结合被内化,其外毒素部分可抑制蛋白质合成并诱导肿瘤细胞凋亡 (apoptosis)。Bizaxofusp 可用于肿瘤的研究。

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CAS No. : 1236019-35-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bizaxofusp (MDNA55) is a fusion protein formed by the linkage of IL-4 and a truncated Pseudomonas exotoxin. Bizaxofusp can bind to IL-4 receptors on the surface of tumor cells and be internalized, and its exotoxin moiety can inhibit protein synthesis and induce tumor cell apoptosis. Bizaxofusp can be used in the study of cancer[1].

IC50 & Target

IL4R

Clinical Trial
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • TOXIN_BIG-PROTEIN
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Bizaxofusp
目录号:
HY-P990708
需求量: