Calcium hydrogen phosphate dihydrate  (Synonyms: 二水磷酸氢钙; Calcium phosphate dihydrate)

Calcium hydrogen phosphate dihydrate (Calcium phosphate dihydrate) can be found quite frequently in urinary calculi stones. Calcium hydrogen phosphate dihydrate can be used as an excipient, such as diluent, adsorbent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs^[1][2].

Calcium hydrogen phosphate dihydrate 在尿液中的溶解度较低，容易在尿液中沉淀并形成晶体，导致肾结石或膀胱结石^[2][3]。
Calcium hydrogen phosphate dihydrate 是羟基磷灰石的前体，可参与骨形成过程^[3]。
Calcium hydrogen phosphate dihydrate 可作为钙补充剂，在早餐谷物、狗粮、面粉和面条中作为食品添加剂^[3]。
Calcium hydrogen phosphate dihydrate 可作为药物制剂中的片剂崩解剂^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

172.09

CaH₅O₆P

7789-77-7

固体

White to off-white

二水磷酸氢钙

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Madhurambal G, et al. Crystallization and thermal characterization of calcium hydrogen phosphate dihydrate crystals[J]. Journal of thermal analysis and calorimetry, 2009, 96(1): 73-76.

  [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [3]. Rajendran K, et al., Growth and characterization of calcium hydrogen phosphate dihydrate crystals from single diffusion gel technique[J]. Crystal Research and Technology, 2010, 45(9): 939-945.