2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. CD2665

CD2665 是一种能口服的选择性 RAR-β,γ 拮抗剂，对 RAR-β 和 RAR-γ 作用的 Kd 值分别为 306 nM，110 nM。CD2665 与 RAR-α 处无结合。

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CD2665 Chemical Structure

CD2665 Chemical Structure

CAS No. : 170355-78-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1285
In-stock
1 mg ￥500
In-stock
5 mg ￥1200
In-stock
10 mg ￥2000
In-stock
25 mg ￥4200
In-stock
50 mg ￥6950
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

CD2665 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively[1][3].

IC50 & Target

Ki: 110 nM (RARγ), 306 nM (RARβ)[1]
体外研究
(In Vitro)

CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CD2665 相关抗体:

Cell Proliferation Assay[1]

Cell Line: 3T3 cells
Concentration: 100 nM
Incubation Time: 9 days
Result: Abrogated the antiprolferative effects of ATRA , CD271 (adapalene, an RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level.
体内研究
(In Vivo)

CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice[2].
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice submitted to 10 months of ethanol consumption[2].
Dosage: 0.6 mg/kg
Administration: Subcutaneous injection; daily, for 22 days.
Result: Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
Animal Model: Male and female mice (3 weeks)[3].
Dosage: 1.6 mg/kg
Administration: Oral gavage/intragastric; daily, for 31 days.
Result: Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
分子量

486.60

Formula

C31H34O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (128.44 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0551 mL 10.2754 mL 20.5508 mL
5 mM 0.4110 mL 2.0551 mL 4.1102 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.91%

COA (262 KB) HNMR (280 KB) RP-HPLC (250 KB) MS (73 KB) 元素分析报告 (208 KB)

产品使用指南 (1538 KB)
参考文献

CD2665 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0551 mL 10.2754 mL 20.5508 mL 51.3769 mL
5 mM 0.4110 mL 2.0551 mL 4.1102 mL 10.2754 mL
10 mM 0.2055 mL 1.0275 mL 2.0551 mL 5.1377 mL
15 mM 0.1370 mL 0.6850 mL 1.3701 mL 3.4251 mL
20 mM 0.1028 mL 0.5138 mL 1.0275 mL 2.5688 mL
25 mM 0.0822 mL 0.4110 mL 0.8220 mL 2.0551 mL
30 mM 0.0685 mL 0.3425 mL 0.6850 mL 1.7126 mL
40 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2844 mL
50 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0275 mL
60 mM 0.0343 mL 0.1713 mL 0.3425 mL 0.8563 mL
80 mM 0.0257 mL 0.1284 mL 0.2569 mL 0.6422 mL
100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5138 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD2665170355-78-9CD 2665CD-2665RAR/RXRRetinoic acid receptorsRetinoid X receptorsRARβRARγRAR-αRAR-betaRAR-gammaInhibitorinhibitorinhibit

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