1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK1-IN-3

CDK1-IN-3 

目录号: HY-151407
产品使用指南

CDK1-IN-3 (8g) 是 CDK1 的选择性抑制剂,对 CDK1,CDK2 和 CDK5 的 IC50 值分别为 36.8,305.17 和 369.37 nM。CDK1-IN-3 通过影响细胞周期抑制癌细胞的生长。CDK1-IN-3 可用于癌症的研究。

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CDK1-IN-3 Chemical Structure

CDK1-IN-3 Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK1-IN-3 (8g) is a selective CDK1 inhibitor with IC50s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer[1].

IC50 & Target

CDK1

36.8 nM (IC50)

CDK2

305.17 nM (IC50)

CDK5

369.37 nM (IC50)

体外研究
(In Vitro)

CDK1-IN-3 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells[1].
CDK1-IN-3 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 36.8, 305.17 and 369.37 nM, respectively[1].
CDK1-IN-3 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5655, 3632, 4626, 5265, 5514 and 2829 nM, respectively[1].
CDK1-IN-3 (0.51 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cells over 61%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.51 and 0.74 μM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Downregulated CDK1 protein level compared to untreated cells.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
分子量

555.98

Formula

C28H25ClF3N5O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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CDK1-IN-3
目录号:
HY-151407
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