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Cedazuridine  (Synonyms: E7727)

目录号: HY-109081 纯度: ≥98.0%
COA 产品使用指南

Cedazuridine (E7727) (Compound 7a) 是一种具有口服活性的胞苷脱氨酶 (CDA) 抑制剂,其 IC50 值为 0.4 μM。Cedazuridine 可用于癌症的研究。

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Cedazuridine Chemical Structure

Cedazuridine Chemical Structure

CAS No. : 1141397-80-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1106
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1 mg ¥375
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5 mg ¥750
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10 mg ¥1200
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25 mg ¥2400
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50 mg ¥3840
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100 mg ¥6144
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200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Cedazuridine:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].

IC50 & Target

IC50: 0.4 μM (CDA)[1]

体外研究
(In Vitro)

Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
Dosage: 3 mg/kg
Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
Animal Model: NSGS male mice[2]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.
Clinical Trial
分子量

268.21

Formula

C9H14F2N2O5

CAS 号
性状

固体

颜色

White to off-white

中文名称

西达尿苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 50 mg/mL (186.42 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7284 mL 18.6421 mL 37.2842 mL
5 mM 0.7457 mL 3.7284 mL 7.4568 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

参考文献

Cedazuridine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7284 mL 18.6421 mL 37.2842 mL 93.2105 mL
5 mM 0.7457 mL 3.7284 mL 7.4568 mL 18.6421 mL
10 mM 0.3728 mL 1.8642 mL 3.7284 mL 9.3211 mL
15 mM 0.2486 mL 1.2428 mL 2.4856 mL 6.2140 mL
20 mM 0.1864 mL 0.9321 mL 1.8642 mL 4.6605 mL
25 mM 0.1491 mL 0.7457 mL 1.4914 mL 3.7284 mL
30 mM 0.1243 mL 0.6214 mL 1.2428 mL 3.1070 mL
40 mM 0.0932 mL 0.4661 mL 0.9321 mL 2.3303 mL
50 mM 0.0746 mL 0.3728 mL 0.7457 mL 1.8642 mL
60 mM 0.0621 mL 0.3107 mL 0.6214 mL 1.5535 mL
80 mM 0.0466 mL 0.2330 mL 0.4661 mL 1.1651 mL
100 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.9321 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cedazuridine
目录号:
HY-109081
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