2. Apoptosis Epigenetics Cell Cycle/DNA Damage Others
  3. Bcl-2 Family Caspase PARP Apoptosis Fluorescent Dye
  4. Chlorin e6

Chlorin e6  (Synonyms: Ce6)

目录号: HY-13594 纯度: 98.49%
COA 产品使用指南 技术支持

Chlorin e6 是一种光敏剂，在波长 402 和 662 nm 处有较强的吸收峰，在 668 nm 处表现出强烈的荧光。Chlorin e6 具有抗菌功效和抗癌活性。Chlorin e6 通过激活 caspase-3 诱导细胞凋亡，可用于癌症的研究。

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Chlorin e6

Chlorin e6 Chemical Structure

CAS No. : 19660-77-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥880
In-stock
50 mg ￥800
In-stock
100 mg ￥1300
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Chlorin e6:

Chlorin e6 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer[1][2][3].

IC50 & Target

Leishmania

 

Bax

 

Bcl-2

 

Caspase 3

 

PARP-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
> 50 μM
Compound: Ce6
Dark toxicity in human HeLa cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human HeLa cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
HeLa IC50
1.92 μM
Compound: Ce6
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
HEp-2 IC50
> 400 μM
Compound: 5
Cytotoxicity against human Hep2 cells under dark condition after 18 hrs by celltiter blue assay
Cytotoxicity against human Hep2 cells under dark condition after 18 hrs by celltiter blue assay
[PMID: 21936519]
HEp-2 IC50
20.8 μM
Compound: 5
Cytotoxicity against human Hep2 cells after overnight incubation followed by cells irradiated with 1 J/cm'2 light for 20 mins measured after overnight incubation by celltiter blue assay
Cytotoxicity against human Hep2 cells after overnight incubation followed by cells irradiated with 1 J/cm'2 light for 20 mins measured after overnight incubation by celltiter blue assay
[PMID: 21936519]
HepG2 IC50
41.2 μM
Compound: Chlorin e6
Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay
Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay
[PMID: 26306981]
HepG2 IC50
52.9 μM
Compound: Chlorin e6
Dark toxicity in human HepG2 cells after overnight incubation by MTT assay
Dark toxicity in human HepG2 cells after overnight incubation by MTT assay
[PMID: 26306981]
MCF7 IC50
> 50 μM
Compound: Ce6
Dark toxicity in human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
MCF7 IC50
3.4 μM
Compound: Ce6
Phototoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
SK-OV-3 IC50
0.39 μM
Compound: Chlorine E6
Photocytotoxicity in human SKOV3 cells assessed as cell death incubated for 6 hrs followed by PDT-1200 light irradiation at 20 J/cm2 measured after 16 hrs using liposome-encapsulated compound by MTT assay
Photocytotoxicity in human SKOV3 cells assessed as cell death incubated for 6 hrs followed by PDT-1200 light irradiation at 20 J/cm2 measured after 16 hrs using liposome-encapsulated compound by MTT assay
[PMID: 29670694]
SW480 IC50
> 50 μM
Compound: Ce6
Dark toxicity in human SW480 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human SW480 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
SW480 IC50
3.1 μM
Compound: Ce6
Phototoxicity against human SW480 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human SW480 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
体外研究
(In Vitro)

Chlorin e6 (100 μg/mL, 24 h) 在 635 nm 激光照射下对 HT-29 细胞中没有毒性[2]。
Chlorin e6 (5-10 μM, 3 h) 在 660 nm 近红外激光照射下通过激活 caspase-3 诱导胰腺癌细胞凋亡，从而抑制 AsPC-1 和 MIA PaCa-2 细胞的肿瘤生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorin e6 相关抗体:

Western Blot Analysis[3]

Cell Line: AsPC-1 and MIA PaCa-2 Cells
Concentration: 5 μM, 10 μM
Incubation Time: 3 h
Result: Significantly reduced Bcl-2 protein expression while increasing apoptotic molecule expression of Bax.
Activated caspase-3 through its cleavage and upregulated the expression of cleaved PARP-1 in a dose-dependent manner.
体内研究
(In Vivo)

Chlorin e6 (2.5 mg/kg，静脉注射，单次剂量) 以 100 J/cm2 的红光照射 8 min 20 s 在 B16F10 黑色素瘤细胞和 PANC02 胰腺细胞异种移植小鼠模型中具有抗肿瘤活性[3]。
Chlorin e6 (2.5 mg/kg，静脉注射，单次剂量) 在 660 nm 近红外激光照射下可抑制犬肿瘤生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse[3]
Dosage: 2.5 mg/kg
Administration: Intravenous injection (i.v.)
Result: Significantly reduced tumor volume.
分子量

596.67

Formula

C34H36N4O6
CAS 号
性状

固体

颜色

Brown to black

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (33.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6760 mL 8.3798 mL 16.7597 mL
5 mM 0.3352 mL 1.6760 mL 3.3519 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.49%

COA (301 KB) HNMR (148 KB) RP-HPLC (168 KB) LCMS (384 KB)

产品使用指南 (1538 KB)
参考文献

Chlorin e6 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6760 mL 8.3798 mL 16.7597 mL 41.8992 mL
5 mM 0.3352 mL 1.6760 mL 3.3519 mL 8.3798 mL
10 mM 0.1676 mL 0.8380 mL 1.6760 mL 4.1899 mL
15 mM 0.1117 mL 0.5587 mL 1.1173 mL 2.7933 mL
20 mM 0.0838 mL 0.4190 mL 0.8380 mL 2.0950 mL
25 mM 0.0670 mL 0.3352 mL 0.6704 mL 1.6760 mL
30 mM 0.0559 mL 0.2793 mL 0.5587 mL 1.3966 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorin e619660-77-6Ce6Chlorin e 6Chlorin e-6Ce 6Ce-6Bcl-2 FamilyCaspasePARPApoptosisFluorescent Dyepoly ADP ribose polymerase Mouse lewis lung cancer cell linesAsPC-1 cellsMIA PaCa-2 cellsB16F10 cellsB16F10 melanoma cells xenograft mouse ,PANC02 pancreatic cells xenograft mouseHT-29 cellsInhibitorinhibitorinhibit

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