1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. CL2A-SN-38

CL2A-SN-38 

目录号: HY-128946
产品使用指南

CL2A-SN-38,SN-38 衍生物,肽连接体。CL2A-SN-38 与抗 Trop-2 人源化抗体缀合,形成抗体药物偶联物 (ADC),针对人类实体瘤表现出特异性的抗肿瘤作用。

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CL2A-SN-38 Chemical Structure

CL2A-SN-38 Chemical Structure

CAS No. : 1279680-68-0

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Description

CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].

IC50 & Target

Alkyl/ether

 

Molecular Weight

1480.61

Formula

C₇₃H₉₇N₁₁O₂₂

CAS No.

1279680-68-0

SMILES

O=C(O[C@@]1(CC)C2=C(C(N3CC4=C(C5=C(C(O)=CC=C5N=C4C3=C2)CC6=CC=C(C=C6)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CC8)CN9C(C=CC9=O)=O)=O)=C7)=O)=O)CCCCN)=O)CC)=O)COC1=O)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CL2A-SN-38
目录号:
HY-128946
需求量:

CL2A-SN-38

Cat. No.: HY-128946