1. Cell Cycle/DNA Damage
  2. Polo-like Kinase (PLK)
  3. Cyclapolin 9

Cyclapolin 9 

目录号: HY-15159
产品使用指南

Cyclapolin 9 是一种有效的,选择性的和 ATP 竞争性 polo-like kinase 1 (PLK1) 抑制剂,IC50 为 500 nM,对其他激酶没有活性。

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Cyclapolin 9 Chemical Structure

Cyclapolin 9 Chemical Structure

CAS No. : 40533-25-3

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Description

Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].

IC50 & Target[2]

PLK1

500 nM (IC50)

In Vitro

Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1].

Molecular Weight

307.21

Formula

C₉H₄F₃N₃O₄S

CAS No.

40533-25-3

SMILES

O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cyclapolin 9Cyclapolin9Cyclapolin-9Polo-like Kinase (PLK)PLK1ATP-competitiveantitumorprostateα1-adrenergicInhibitorinhibitorinhibit

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产品名称:
Cyclapolin 9
目录号:
HY-15159
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