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  3. D-α-Tocopherol Succinate

D-α-Tocopherol Succinate  (Synonyms: D-α-生育酚琥珀酸酯; Vitamin E succinate)

目录号: HY-131553 纯度: ≥98.0%
COA 产品使用指南

D-α-Tocopherol Succinate (Vitamin E succinate) 是一种抗氧化生育酚,是维生素 E 的一种盐形式。D-α-Tocopherol Succinat 抑制 Cisplatin (HY-17394) 引起的毒性。D-α-Tocopherol Succinate 可用于癌症的研究。

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D-α-Tocopherol Succinate Chemical Structure

D-α-Tocopherol Succinate Chemical Structure

CAS No. : 4345-03-3

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Other Forms of D-α-Tocopherol Succinate:

MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
10 μM
Compound: 1, VES
Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
[PMID: 19708661]
HCT-116 IC50
52.3 μM
Compound: alpha-TOS
Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
10.1007/s00044-011-9801-3
HepG2 IC50
245 μM
Compound: alpha-TOS
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
HepG2 IC50
55 μM
Compound: alpha-TOS
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
10.1007/s00044-011-9801-3
MCF7 IC50
57 μM
Compound: alpha-TOS
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
MT4 IC50
66 μM
Compound: alpha-TOS
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
RPMI-8226 IC50
63 μM
Compound: alpha-TOS
Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
U-937 IC50
113 μM
Compound: alpha-TOS
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
体外研究
(In Vitro)

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1].
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1].
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 1-20 μM
Incubation Time: 24 hours
Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 10 μM
Incubation Time: 48 hours
Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay[2]

Cell Line: TC-1 tumor cells
Concentration: 0, 25 and 50 μM
Incubation Time: 18 hours
Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
体内研究
(In Vivo)

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2]
Dosage: 1 and 2 mg/kg
Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
分子量

530.78

Formula

C33H54O5

CAS 号
性状

固体

颜色

White to off-white

中文名称

D-α-生育酚琥珀酸酯;维生素E琥珀酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 250 mg/mL (471.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8840 mL 9.4201 mL 18.8402 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8840 mL 9.4201 mL 18.8402 mL 47.1005 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL 9.4201 mL
10 mM 0.1884 mL 0.9420 mL 1.8840 mL 4.7100 mL
15 mM 0.1256 mL 0.6280 mL 1.2560 mL 3.1400 mL
20 mM 0.0942 mL 0.4710 mL 0.9420 mL 2.3550 mL
25 mM 0.0754 mL 0.3768 mL 0.7536 mL 1.8840 mL
30 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5700 mL
40 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1775 mL
50 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9420 mL
60 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7850 mL
80 mM 0.0236 mL 0.1178 mL 0.2355 mL 0.5888 mL
100 mM 0.0188 mL 0.0942 mL 0.1884 mL 0.4710 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
D-α-Tocopherol Succinate
目录号:
HY-131553
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