2. PROTAC
  3. PROTACs Ligands for E3 Ligase
  4. DA-PROTAC

DA-PROTAC 是一种有效的铜离子转运蛋白 Atox1 和 CCS 的 PROTAC 降解剂。DA-PROTAC 可结合 Atox1 和 CCS 蛋白，而该复合物可结合 E3 连接酶，导致 Atox1 和 CCS 泛素化水平升高，并通过蛋白酶体途径降解 Atox1 和 CCS 蛋白。DA-PROTAC可用于三阴性乳腺癌研究。

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DA-PROTAC Chemical Structure

DA-PROTAC Chemical Structure

CAS No. : 2488660-12-2

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

DA-PROTAC 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Ligands for E3 Ligase 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research[1].

IC50 & Target

VHL

 

体外研究
(In Vitro)

DA-PROTAC (0-1 μM, 24 h) can degrade Atox1 and CCS proteins rather than inhibit Atox1 and CCS activity[1].
DA-PROTAC (5 μM, 24 h) inhibits the proliferation, migration and invasion of triple negative breast cancer cells (MDA-MB-231)[1].
DA-PROTAC (10 μM, 48 h) inhibits the tumorigenic capacity of triple negative breast cancer cells (MDA-MB-231)[1].
The targeting module of DA-PROTAC is a small molecule VHL ligand1 combined with E3 ligase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DA-PROTAC 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 100 nM ,200 nM ,500 nM , and 1000 nM
Incubation Time: 24 h
Result: Significantly reduced ATOX1 and CCS protein levels under 200nM, indicating that DA-PROTAC can degrade ATOX1 and CCS proteins.
分子量

1010.96

Formula

C46H50BrF2N7O8S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DA-PROTAC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DA-PROTAC2488660-12-2PROTACsLigands for E3 LigaseE3 ligase-recruiting Moietytriple negative breast cancerMDA-MB-231 cellsVHL ligand1E3 ligaseAtox1CCScopper ion-transport proteinsproteasomeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147373
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