2. Metabolic Enzyme/Protease MAPK/ERK Pathway Apoptosis
  3. Proteasome Ribosomal S6 Kinase (RSK) Apoptosis
  4. DD1

DD1 是一种蛋白酶体 (proteasome) 抑制剂，在急性髓细胞白血病 (AML) 凋亡过程中，激活 Bax，降解 P70S6K。DD1 以 caspase 依赖性方式诱导细胞凋亡。DD1 诱导线粒体膜去极化和 Bad 去磷酸化。

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DD1 Chemical Structure

DD1 Chemical Structure

CAS No. : 187585-11-1

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规格 价格 是否有货 数量
1 mg ￥2696
1 周
5 mg   询价  
10 mg   询价  

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DD1 相关抗体

Top Publications Citing Use of Products

查看 Ribosomal S6 Kinase (RSK) 亚型特异性产品:

查看所有亚型
p70S6K RSK1 RSK2 RSK3 RSK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

IC50 & Target

p70S6K

 

体外研究
(In Vitro)

DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1].
DD1 induces cell cycle arrest at G2/M phase and apoptosis[1].
DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1].
DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DD1 相关抗体:
分子量

282.29

Formula

C16H14N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DD1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DD1187585-11-1DD 1DD-1ProteasomeRibosomal S6 Kinase (RSK)ApoptosisS6Kproteasome inhibitorBax activationP70S6K degradationacute myeloid leukemiaapoptosismitochondrial membrane depolarizationBad dephosphorylationInhibitorinhibitorinhibit

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