2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Tyrosinase Sirtuin
  4. Decapeptide-12

Decapeptide-12  (Synonyms: 十肽-12)

目录号: HY-P0096
产品使用指南

摩尔计算器

Decapeptide-12，一种小寡肽，是一种酪氨酸酶 (tyrosinase) 抑制剂，可与酪氨酸酶的 C 末端残基相互作用 (Kd: 61.1 μM)。Decapeptide-12 是蘑菇酪氨酸酶 (mushroom tyrosinase) 的竞争性抑制剂 (IC50: 40 µM)。Decapeptide-12 上调 SIRT 的转录水平。Decapeptide-12 可降低黑色素细胞中黑色素的含量，可用于研究黑色素生成、衰老、炎症。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Decapeptide-12 Chemical Structure

Decapeptide-12 Chemical Structure

CAS No. : 137665-91-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Decapeptide-12 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

IC50 & Target

IC50: 40 µM (Tyrosinase)[1], Kd: 61.1 μM (Tyrosinase)[2].
体外研究
(In Vitro)

Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 µM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Decapeptide-12 相关抗体:

Cell Proliferation Assay[3]

Cell Line: Phytohemagglutinin (PHA)-stimulated PBMC cells
Concentration: 0, 0.025, 0.05, 0.1, 0.3, 1 mM
Incubation Time: 72 h
Result: Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.

RT-PCR[3]

Cell Line: Human neonatal keratinocyte progenitors
Concentration: 3, 10, 30, 50, 100, 300, 500, 1000 μM
Incubation Time: 72 h
Result: Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
分子量

1395.52

Formula

KS3WY3
CAS 号
Sequence Shortening

YRSRKYSSWY
中文名称

十肽-12
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Decapeptide-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decapeptide-12137665-91-9十肽-12Decapeptide12Decapeptide 12TyrosinaseSirtuinMelanocytesmelaninmelanogenesismushroom tyrosinasemonophenolaseoligopeptideanti-senescenceanti-aginganti-inflammationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Decapeptide-12
目录号：
HY-P0096
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z