1. Immunology/Inflammation Apoptosis
  2. COX Apoptosis
  3. Diclofenac-d4 sodium

Diclofenac-d4 sodium  (Synonyms: 双氯芬酸钠 d4 (钠盐))

目录号: HY-15037S1 纯度: ≥99.0%
COA 产品使用指南

Diclofenac-d4 (sodium) 是 Diclofenac sodium 的氘代物。Diclofenac Sodium (GP 45840) 是一种有效的,非选择性抗炎剂,为 COX 的抑制剂,在 CHO 细胞中,对人 COX-1COX-2IC50 值分别为 4 和 1.3 nM。Diclofenac Sodium 对绵羊 COX-1COX-2IC50 值分别为 5.1 μM,0.84 μM。Diclofenac Sodium 通过活化 caspase 级联反应来诱导神经干细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Diclofenac-d<sub>4</sub> sodium Chemical Structure

Diclofenac-d4 sodium Chemical Structure

CAS No. : 154523-54-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥6800
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Diclofenac-d4 sodium:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

322.16

Formula

C14H6D4Cl2NNaO2

CAS 号
性状

固体

颜色

White to off-white

中文名称

双氯芬酸钠 d4 (钠盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥99.0%

参考文献

Diclofenac-d4 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Diclofenac-d4 sodium
目录号:
HY-15037S1
需求量: