1. 疾病领域
  2. 神经系统疾病
  3. 疼痛
  4. 慢性疼痛

Chronic Pain  (慢性疼痛)

慢性疼痛是一种持续至少三个月的持续性或复发性疼痛状态,超出正常的愈合期,且并非由持续的组织损伤直接引起。它是一种受生物、心理、社会、文化和环境因素影响的复杂综合征,其特征是与实际或潜在的组织损伤相关的不适感觉和情绪体验。慢性疼痛通常在急性损伤或疾病恢复后持续存在,可能没有可识别的病因,并且严重影响所有年龄段人群的身体功能、情绪健康和生活质量,老年人和女性的患病率更高。

Chronic pain is a persistent or recurrent painful condition lasting at least three months, extending beyond the normal healing period and not directly attributable to ongoing tissue damage. It is a complex syndrome influenced by biological, psychological, social, cultural, and environmental factors, characterized by an unpleasant sensory and emotional experience associated with actual or potential tissue injury. Chronic pain often persists after recovery from acute injury or illness, may have no identifiable cause, and significantly impacts physical function, emotional health, and quality of life across all age groups, with higher prevalence observed in older adults and women.

参考文献:

Chronic Pain (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14406
    L-733060 148700-85-0
    L-733060 是一种选择性的神经激肽-1 受体 (NK-1 receptor) 拮抗剂。L-733060 主要通过阻断 Substance P (P 物质) 与 NK-1 受体的结合来调控痛觉传递和神经可塑性能阻断 L-733060 阻断 Substance P 在海马体中对长时程增强 (LTP) 的促进作用。L-733060 逆转大鼠由实验性咬合干扰 (EOI) 诱导的口面部痛觉过敏。L-733060 hydrochloride 以不会在啮齿动物中引起不良心血管影响的剂量抑制神经源性血浆外渗,同时还充当抗肿瘤剂。L-733060 可用于研究慢性口面部疼痛和恶性黑色素瘤。
    L-733060