2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. L-733060

L-733060 是一种选择性的神经激肽-1 受体 (NK-1 receptor) 拮抗剂。L-733060 主要通过阻断 Substance P (P 物质) 与 NK-1 受体的结合来调控痛觉传递和神经可塑性能阻断 L-733060 阻断 Substance P 在海马体中对长时程增强 (LTP) 的促进作用。L-733060 逆转大鼠由实验性咬合干扰 (EOI) 诱导的口面部痛觉过敏。L-733060 hydrochloride 以不会在啮齿动物中引起不良心血管影响的剂量抑制神经源性血浆外渗，同时还充当抗肿瘤剂。L-733060 可用于研究慢性口面部疼痛和恶性黑色素瘤。

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L-733060

L-733060 Chemical Structure

CAS No. : 148700-85-0

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L-733060 的其他形式现货产品:

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L-733060 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Neurokinin Receptor 亚型特异性产品:

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NK1R NK2R NK3R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-733060 is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 can be used for the study of chronic orofacial pain[1][2][3].

IC50 & Target[1][2]

NK1R

 

分子量

403.36

Formula

C20H19F6NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-733060 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-733060148700-85-0L733060L 733060Neurokinin ReceptorNK receptorTachykinin receptorNK-1 receptor antagonistorofacial hyperalgesiarostral ventromedial medulladescending pain modulationchronic pain maintenanceInhibitorinhibitorinhibit

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