1. Stem Cell/Wnt
    TGF-beta/Smad
    PI3K/Akt/mTOR
  2. TGF-beta/Smad
    PI3K
  3. Disitertide TFA

Disitertide TFA (Synonyms: P144 TFA)

目录号: HY-P0118A 纯度: 96.40%
产品使用指南

Disitertide (P144) TFA 是 TGFβ1 的多肽抑制剂,特异性的阻断其与受体间的相互作用。Disitertide (P144) 也是PI3K 的抑制剂。

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Custom Peptide Synthesis

Disitertide TFA Chemical Structure

Disitertide TFA Chemical Structure

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Size Price Stock Quantity
1 mg ¥2000 In-stock
5 mg ¥5500 In-stock
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Customer Review

Other Forms of Disitertide TFA:

Top Publications Citing Use of Products

    Disitertide TFA purchased from MCE. Usage Cited in: Cell Death Differ. 2020 Jul 31.

    LINC00941-overexpressing cells treated with Disitertide (10 μM) shows increased mRNA and protein levels of ZO-1 and Ecadherin compared with controls. LINC00941-silenced cells show decreased mRNA and protein levels of ZO-1 and E-cadherin but increased mRNA and protein levels of Vimentin, Fibronectin, and Twist1.
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    • 参考文献

    Description

    Disitertide (P144) TFA is a peptidic TGFβ1 inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor[1][2].

    In Vitro

    Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells[2].
    Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance[3].

    Western Blot Analysis[2]

    Cell Line: Mouse embryo osteoblast precursor MC3T3-E1 cells.
    Concentration: 100 μg/mL.
    Incubation Time: 4 h.
    Result: Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.
    In Vivo

    Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment[4].

    Animal Model: Human hypertrophic scars were implanted in 60 nude mice[4].
    Dosage: 300 μg/mL was added the Lipogel.
    Administration: Topical application daily administered.
    Result: Successful shedding was achieved in 83,3% of the xenografts.
    Molecular Weight

    1694.84

    Formula

    C₇₀H₁₁₀N₁₇O₂₄S₂F₃

    Sequence Shortening

    TSLDASIIWAMMQN

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Protect from light
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    References
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    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    DisitertideP144P 144P-144TGF-beta/SmadPI3KTransforming growth factor betaPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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    产品名称:
    Disitertide TFA
    目录号:
    HY-P0118A
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