1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Dostarlimab

Dostarlimab  (Synonyms: TSR-042)

目录号: HY-P99345 纯度: 95.00%
COA

Dostarlimab (TSR-042) 是一种人源化抗 PD-1 单克隆抗体。Dostarlimab 与人 PD-1 具有高亲和力,并竞争性地抑制其与其配体 PD-L1 和 PD-L2 的相互作用,IC50s 分别为 1.8 nM 和 1.5 nM。

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Dostarlimab Chemical Structure

Dostarlimab Chemical Structure

CAS No. : 2022215-59-2

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1].

IC50 & Target

IC50: 1.5 nM (PD-L2/ PD-1), 1.8 nM (PD-L1/ PD-1)[1]

体外研究
(In Vitro)

Dostarlimab (10-10000 ng/mL) 以剂量依赖的方式与人和食蟹猴 CD3+ T 细胞上表达的原生 PD-1 受体结合[1]
Dostarlimab (0-375 nM; 48 h) 在人 CD4+ T 细胞 MLR 实验中增加 IL-2 的产生,EC50 大约为 1 nM,在葡萄球菌肠毒素 B (SEB) 刺激的 PBMC 细胞中增加 IL-2 的产生,EC50 大约为 0.1 nM,增强干扰素 (IFN)-γ 的释放,EC50 大约为 0.5 nM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Dostarlimab (200 µg/mouse; i.p.; twice weekly for 35 days) 在人源化小鼠模型中显示出抗肿瘤活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized NOG-EXL mice, A549 and MDA-MB-436 tumor model[1]
Dosage: 200 µg/mouse
Administration: Intraperitoneal injection; twice weekly for 35 days
Result: Resulted in great inhibition of tumor growth in an A549 lung cancer model (tumor growth inhibition [TGI] of 62% at termination). The antitumor activity was associated with a reduction in tumor-associated regulatory T cells and a trend toward increased tumor-infiltrating CD8+ T cells. Inhibited tumor growth of MDA-MB-436 breast cancer model (TGI of 53%).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Dostarlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
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