2. Anti-infection
  3. Parasite
  4. ELQ-598

ELQ-598 作为一种前体药物，它通过口服形式在体内转变为活性药物 ELQ-596。ELQ-598 显示出强效的寄生虫生长抑制能力 (IC50= 37 nM)，以及对人类细胞的低毒性 (IC50= 19 μM)。ELQ-598 能够用于巴贝斯虫病的研究。

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ELQ-598 Chemical Structure

ELQ-598 Chemical Structure

CAS No. : 3023709-99-8

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ELQ-598 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis[1].

体内研究
(In Vivo)

ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 完全消除了 C3H 小鼠的邓肯芽孢杆菌感染[1]。
ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 可有效消除小鼠的微小芽孢杆菌感染[1]。
ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 联合 atovaquone (HY-13832) 可以消除 C3H/HeJ 小鼠中的邓肯芽孢杆菌感染和 SCID 小鼠的微小芽孢杆菌感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H mice genetically prone to B. duncani infection[1]
Dosage: 10mg/kg
Administration: p.o.; daily DPI 3-7
Result: Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed.
Animal Model: C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection[1]
Dosage: 10mg/kg with 10mg/kg atovaquone,
Administration: p.o.; daily DPI 3-7
Result: All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone.
分子量

561.93

Formula

C28H23ClF3NO6
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ELQ-598 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELQ-5983023709-99-8ELQ598ELQ 598ParasiteAntiparasiticProdrug of ELQ-596BabesiosisMitochondrial Cytochrome bc1 InhibitorC3H miceSCID miceInhibitorinhibitorinhibit

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产品名称：
ELQ-598
目录号：
HY-163483
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