1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Estrogen receptor-IN-1

Estrogen receptor-IN-1 (compound 16) 是一种有效的雌激素受体estrogen receptor (ER) 抑制剂,对 ERαErβIC50 值分别为 13 和 5µM。

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Estrogen receptor-IN-1 Chemical Structure

Estrogen receptor-IN-1 Chemical Structure

CAS No. : 74027-99-9

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MCE 顾客使用本产品发表的 1 篇科研文献

查看 Estrogen Receptor/ERR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].

IC50 & Target[1]

ERα

13 μM (IC50)

ERβ

5 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
> 30 μM
Compound: 16
Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
[PMID: 31980362]
HEK293 IC50
13 μM
Compound: 16
Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
[PMID: 31980362]
HEK293 IC50
5 μM
Compound: 16
Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay
[PMID: 31980362]
MCF7 EC50
16 nM
Compound: 16
Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay
Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay
[PMID: 23214428]
分子量

228.36

Formula

C14H16OSi

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Estrogen receptor-IN-1
目录号:
HY-150601
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